Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

• GO:0030036 : actin cytoskeleton organization
• GO:0030521 : androgen receptor signaling pathway
• GO:0043297 : apical junction assembly
• GO:0007411 : axon guidance
• GO:0007160 : cell-matrix adhesion
• GO:0036089 : cleavage furrow formation
• GO:0050771 : negative regulation of axonogenesis
• GO:0033144 : negative regulation of intracellular steroid hormone receptor signaling pathway
• GO:0043524 : negative regulation of neuron apoptotic process
• GO:0048011 : nerve growth factor receptor signaling pathway
• GO:0043931 : ossification involved in bone maturation
• GO:0048015 : phosphatidylinositol-mediated signaling
• GO:0030168 : platelet activation
• GO:0050772 : positive regulation of axonogenesis
• GO:0071777 : positive regulation of cell cycle cytokinesis
• GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
• GO:0045666 : positive regulation of neuron differentiation
• GO:0042346 : positive regulation of NF-kappaB import into nucleus
• GO:0051496 : positive regulation of stress fiber assembly
• GO:0030334 : regulation of cell migration
• GO:0033688 : regulation of osteoblast proliferation
• GO:0051056 : regulation of small GTPase mediated signal transduction
• GO:0006357 : regulation of transcription from RNA polymerase II promoter
• GO:0007266 : Rho protein signal transduction
• GO:0007519 : skeletal muscle tissue development
• GO:0090307 : spindle assembly involved in mitosis
• GO:0043149 : stress fiber assembly
• GO:0061383 : trabecula morphogenesis
• GO:0007179 : transforming growth factor beta receptor signaling pathway
• GO:0019048 : virus-host interaction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/