RhoG / TRP channels
Name: Rho-related GTP-binding protein RhoG
(RhoG)
Official Symbol: RHOG
provided by HGNC
Function:
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
391 |
P84095 |
DIP-31094N |
P84095 |
MINT-4132365 |
106884 |
P84095 |
hsa:391 |
179505 |
|
|
Mouse
|
56212 |
P84096 |
MINT-4132387 |
207846 |
P84096 |
mmu:56212 |
||||
|
Rat
|
308875 |
Q32PX6 |
DIP-37390N |
Q32PX6 |
UNK-5400289 |
259177 |
Q32PX6 |
rno:308875 |
||
PPI pairs:
Biological Process:
- GO:0030036
: actin cytoskeleton organization - GO:0032863 : activation of Rac GTPase activity
- GO:0007411 : axon guidance
- GO:0060326 : cell chemotaxis
- GO:0030168 : platelet activation
- GO:0008284 : positive regulation of cell proliferation
- GO:0090004 : positive regulation of establishment of protein localization to plasma membrane
- GO:0045893 : positive regulation of transcription, DNA-templated
- GO:0016601 : Rac protein signal transduction
- GO:0007266 : Rho protein signal transduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPML1 |
|
RhoG | Speculation | Prediction | 23418601 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPML1 |
|
RhoG | Co-immunofluorescence staining | RAW264.7 macrophage | Mouse | Full-length | Mouse | Full-length | 23418601 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)