RyR1 / TRP channels
Name: Ryanodine receptor 1
(RyR1)
Official Symbol: RYR1
provided by HGNC
Function:
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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6261![]() |
P21817![]() |
DIP-29708N![]() |
P21817![]() |
MINT-1605046![]() |
112173![]() |
P21817![]() |
hsa:6261![]() |
180901![]() |
|
Mouse
![]() |
20190![]() |
Q80X16![]() |
DIP-29705N![]() |
Q80X16![]() |
203045![]() |
Q80X16![]() |
mmu:20190![]() |
|||
Rat
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114207![]() |
F1LMY4![]() |
MINT-195292![]() |
250309![]() |
rno:114207![]() |
Biological Process:
- GO:0071313
: cellular response to caffeine
- GO:0006936
: muscle contraction
- GO:0043931
: ossification involved in bone maturation
- GO:0003151
: outflow tract morphogenesis
- GO:0014808
: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- GO:0001666
: response to hypoxia
- GO:0048741
: skeletal muscle fiber development
- GO:0043588
: skin development
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:180901
: Malignant hyperthermia susceptibility 1 (OMIM:145600
)
- OMIM:180901
: Central core disease (OMIM:117000
)
- OMIM:180901
: Minicore myopathy with external ophthalmoplegia (OMIM:255320
)
- OMIM:180901
: Neuromuscular disease, congenital, with uniform type 1 fiber (OMIM:117000
)
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC1 |
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RyR1 | Affinity purification-mass spectrometry | Not used as a bait | Rabbit | Fast-twitch muscle | Triad vesicles | 18215135 | ||
TRPC5 |
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RyR1 | Affinity purification-mass spectrometry | Not used as a bait | Rabbit | Fast-twitch muscle | Triad vesicles | 18215135 | ||
TRPV1 |
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RyR1 | Affinity purification-mass spectrometry | Not used as a bait | Rabbit | Fast-twitch muscle | Triad vesicles | 18215135 | ||
TRPV6 |
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RyR1 | Affinity purification-mass spectrometry | Not used as a bait | Rabbit | Fast-twitch muscle | Triad vesicles | 18215135 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC1 |
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RyR1 | Co-immunoprecipitation | Mouse skeletal myotube lysates | 18215135 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
