S100A10 / TRP channels
Name: Protein S100-A10
(S100A10)
Official Symbol: S100A10
provided by HGNC
Function:
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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6281![]() |
P60903![]() |
P60903![]() |
MINT-1178035![]() |
112189![]() |
P60903![]() |
hsa:6281![]() |
114085![]() |
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Mouse
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20194![]() |
P08207![]() |
DIP-49529N![]() |
P08207![]() |
MINT-4133605![]() |
203049![]() |
P08207![]() |
mmu:20194![]() |
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Rat
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81778![]() |
P05943![]() |
DIP-46650N![]() |
P05943![]() |
MINT-4586198![]() |
249650![]() |
P05943![]() |
rno:81778![]() |
Biological Process:
- GO:0071229
: cellular response to acid
- GO:0051099
: positive regulation of binding
- GO:0007165
: signal transduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC6 |
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S100A10 | Inference | Prediction | 23671622 | |||||
TRPM3 |
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S100A10 | Inference | Prediction | 22451665 | |||||
TRPV5 |
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S100A10 | Yeast two-hybrid | Mouse | C-terminus | Mouse | Kidney | cDNA library | 12660155 | |
TRPV6 |
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S100A10 | Inference | Prediction | 12660155 | |||||
TRPV6 |
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S100A10 | Yeast two-hybrid | Human | Not specified | Human | Not specified | Not specified | 16189514 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vitro validation
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Assay with recombinant proteins | Reference | |||||||||
TRP channel construct | Interactor construct | |||||||||
TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
TRPC6 |
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S100A10 | Fluorescence probe labeling | Rat | 801-878 | E. coli | Human | Full-length | E. coli | 23671622 |
TRPM3 |
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S100A10 | Fluorescence probe labeling | Human | 35-124 | E. coli | Human | Full-length | E. coli | 22451665 |
TRPM3 |
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S100A10 | Fluorescence probe labeling | Human | 291-382 | E. coli | Human | Full-length | E. coli | 22451665 |
TRPV5 |
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S100A10 | Fusion protein-pull down assay | Mouse | Full-length | E. coli | Mouse | Full-length | Xenopus oocyte lysates | 12660155 |
TRPV6 |
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S100A10 | Fusion protein-pull down assay | Mouse | Full-length | E. coli | Mouse | Full-length | Xenopus oocyte lysates | 12660155 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Validation: In vivo validation
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Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPV5 |
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S100A10 | Co-immunofluorescence staining | Rat duodenum tissue | 12660155 | |||||
TRPV6 |
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S100A10 | Co-immunofluorescence staining | Rat duodenum tissue | 12660155 | |||||
TRPV6 |
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S100A10 | Co-immunoprecipitation | Caco-2 cell | 18187190 | |||||
TRPV6 |
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S100A10 | Co-immunoprecipitation | Human 16HBE14o- cell | 18187190 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Characterization
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Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
TRP channel | Interactor | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPC6 |
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S100A10 | Fluorescence probe labeling | Rat | 801-878 | Human | Not determined | 310 nM | 23671622 | |
TRPM3 |
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S100A10 | Fluorescence probe labeling | Human | 291-382 | Human | Not determined | 22451665 | ||
TRPM3 |
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S100A10 | Fluorescence probe labeling | Human | 35-124 | Human | Not determined | 22451665 | ||
TRPV5 |
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S100A10 | Fusion protein-pull down assay | Mouse | 591-595 | Mouse | Not determined | 12660155 | ||
TRPV6 |
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S100A10 | Fusion protein-pull down assay | Mouse | 597-601 | Mouse | Not determined | 12660155 |
(
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click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

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Functional consequence
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TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
TRPV5 |
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S100A10 | Co-immunofluorescence staining | Increase in plasma membrane level | 12660155 | |||||||
TRPV5 |
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S100A10 | Patch clamp | Activation | 12660155 | |||||||
TRPV6 |
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S100A10 | Co-immunofluorescence staining | Increase in plasma membrane level | 12660155 | |||||||
TRPV6 |
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S100A10 | Patch clamp | Activation | 12660155 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
