SEC61B / TRP channels

Name: Protein transport protein Sec61 subunit beta (SEC61B)
Official Symbol: SEC61B provided by HGNC
Function:
Necessary for protein translocation in the endoplasmic reticulum.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		10952External P60468External DIP-40997NExternal P60468External MINT-106933External 116152External P60468External   hsa:10952External 609214External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		66212External Q9CQS8External DIP-49427NExternal Q9CQS8External   211302External Q9CQS8External   mmu:66212External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		298068External B2RZD1External DIP-57351NExternal   MINT-7138994External 255755External B2RZD1External   rno:298068External  
PPI pairs:
Biological Process:
  • GO:0002479 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • GO:0030433 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : ER-associated protein catabolic process
  • GO:0000060 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : protein import into nucleus, translocation
  • GO:0030970 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : retrograde protein transport, ER to cytosol
  • GO:0006614 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : SRP-dependent cotranslational protein targeting to membrane
  • GO:0006412 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : translation
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SEC61B Affinity purification-mass spectrometry Mouse Not specified Mouse Vascular smooth muscle MOVAS lysates 19879844
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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