SKP1 / TRP channels

Name: S-phase kinase-associated protein 1 (SKP1)
Official Symbol: SKP1 provided by HGNC
Function:
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		6500External P63208External DIP-17012NExternal P63208External MINT-5001195External 112391External P63208External   hsa:6500External 601434External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		21402External Q9WTX5External DIP-38596NExternal Q9WTX5External MINT-4134768External 203998External Q9WTX5External   mmu:21402External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		287280External Q6PEC4External DIP-29863NExternal Q6PEC4External   252084External Q6PEC4External   rno:287280External  
PPI pairs:
Biological Process:
  • GO:0031145 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • GO:0000080 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : G1 phase of mitotic cell cycle
  • GO:0000082 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : G1/S transition of mitotic cell cycle
  • GO:0035518 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : histone H2A monoubiquitination
  • GO:0007219 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : Notch signaling pathway
  • GO:0051437 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • GO:0000084 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : S phase of mitotic cell cycle
  • GO:0031146 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • GO:0016032 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : viral reproduction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SKP1 Affinity purification-mass spectrometry Mouse Not specified Mouse Vascular smooth muscle MOVAS lysates 19879844
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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