SNAP25 / TRP channels
Name: Synaptosomal-associated protein 25
(SNAP25)
Official Symbol: SNAP25
provided by HGNC
Function:
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6616 |
P60880 |
DIP-34554N |
P60880 |
MINT-1403389 |
112500 |
P60880 |
hsa:6616 |
600322 |
|
|
Mouse
|
20614 |
P60879 |
DIP-29066N DIP-65N |
P60879 |
MINT-2411221 |
203362 |
P60879 |
mmu:20614 |
||
|
Rat
|
25012 |
P60881 |
DIP-29205N DIP-29593N |
P60881 |
MINT-95953 |
247095 |
P60881 |
rno:25012 |
||
Biological Process:
- GO:0007409
: axonogenesis - GO:0048791 : calcium ion-dependent exocytosis of neurotransmitter
- GO:0016197 : endosomal transport
- GO:0006112 : energy reserve metabolic process
- GO:0014047 : glutamate secretion
- GO:0030252 : growth hormone secretion
- GO:0007616 : long-term memory
- GO:0001504 : neurotransmitter uptake
- GO:0032024 : positive regulation of insulin secretion
- GO:0050796 : regulation of insulin secretion
- GO:0051963 : regulation of synapse assembly
- GO:0030431 : sleep
- GO:0044281 : small molecule metabolic process
- GO:0016081 : synaptic vesicle docking involved in exocytosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC1 |
|
SNAP25 | Inference | Prediction | 15121806 | |||||
| TRPC3 |
|
SNAP25 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC1 |
|
SNAP25 | Co-immunoprecipitation | Human platelets | 15121806 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)