TRP channels

TRPC
- TRPC1
- TRPC2
- TRPC3
- TRPC4
- TRPC5
- TRPC6
- TRPC7
TRPV
- TRPV1
- TRPV2
- TRPV3
- TRPV4
- TRPV5
- TRPV6
TRPM
- TRPM1
- TRPM2
- TRPM3
- TRPM4
- TRPM5
- TRPM6
- TRPM7
- TRPM8
TRPML
- TRPML1
- TRPML2
- TRPML3
TRPP
- TRPP1
- TRPP2
- TRPP3
TRPA
- TRPA1

» Citation

Nar2011 9c5ccb7544ea9ea0a4b3599ccec8bea610f3995142d5da2da0189fad9f699236

Plos2012 71954aaff6a4569630a779eb6502d687ff86630adfca3a1cc207b9836b808980

Pf2013 33c9f49bb4f61555bed5365c90448ebe56e96eb338f5692f7ef4b8a5db693247

SOD2 / TRP channels

Basic Information
External Database
PPI pairs (1)
Biological Process (43)
Disease (1)

Name: Superoxide dismutase [Mn], mitochondrial (SOD2)

Official Symbol: SOD2 provided by HGNC

Function:

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species

External DB

Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984

Entrez Gene

UniprotKB

DIP

IntAct

MINT

BioGRID

STRING

IUPHAR-DB

KEGG

OMIM

Human

Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f

Mouse

Rat

PPI pairs:

Biological Process:

GO:0001315 : age-dependent response to reactive oxygen species
GO:0071361 : cellular response to ethanol
GO:0003032 : detection of oxygen
GO:0048773 : erythrophore differentiation
GO:0006749 : glutathione metabolic process
GO:0007507 : heart development
GO:0030097 : hemopoiesis
GO:0050665 : hydrogen peroxide biosynthetic process
GO:0055072 : iron ion homeostasis
GO:0001889 : liver development
GO:0007626 : locomotory behavior
GO:0008285 : negative regulation of cell proliferation
GO:0045599 : negative regulation of fat cell differentiation
GO:0048147 : negative regulation of fibroblast proliferation
GO:0043524 : negative regulation of neuron apoptotic process
GO:0048666 : neuron development
GO:0032364 : oxygen homeostasis
GO:0045429 : positive regulation of nitric oxide biosynthetic process
GO:0009791 : post-embryonic development
GO:0051289 : protein homotetramerization
GO:0050790 : regulation of catalytic activity
GO:0051881 : regulation of mitochondrial membrane potential
GO:0006357 : regulation of transcription from RNA polymerase II promoter
GO:0001836 : release of cytochrome c from mitochondria
GO:0019430 : removal of superoxide radicals
GO:0022904 : respiratory electron transport chain
GO:0014823 : response to activity
GO:0048678 : response to axon injury
GO:0046686 : response to cadmium ion
GO:0042493 : response to drug
GO:0051602 : response to electrical stimulus
GO:0010332 : response to gamma radiation
GO:0042542 : response to hydrogen peroxide
GO:0055093 : response to hyperoxia
GO:0001666 : response to hypoxia
GO:0033591 : response to L-ascorbic acid
GO:0032496 : response to lipopolysaccharide
GO:0010042 : response to manganese ion
GO:0010269 : response to selenium ion
GO:0034021 : response to silicon dioxide
GO:0010043 : response to zinc ion
GO:0042554 : superoxide anion generation
GO:0003069 : vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Disease:

OMIM:147460 : Microvascular complications of diabetes 6 (OMIM:612634 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

top

Screening
			Experimental screening					Non-experimental screening	Reference
			TRP channel construct		Interactor source
TRP channel	Interactor	Method	Species	Region	Species	Organ/tissue	Sample type
TRPC3	SOD2	Affinity purification-mass spectrometry	Not used as a bait		Rat	Brain	Crude membranes		18205297

(

Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

TRIP Database

SOD2 / TRP channels