SRA-1 / TRP channels
Name: Cytoplasmic FMR1-interacting protein 1
(SRA-1)
Official Symbol: CYFIP1
provided by HGNC
Function:
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
23191 |
Q7L576 |
DIP-38873N |
Q7L576 |
MINT-1731056 |
116800 |
Q7L576 |
hsa:23191 |
606322 |
|
|
Mouse
|
20430 |
Q7TMB8 |
DIP-32264N |
Q7TMB8 |
MINT-203655 |
203226 |
Q7TMB8 |
mmu:20430 |
||
|
Rat
|
308666 |
D4A8H8 |
259102 |
rno:308666 |
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PPI pairs:
Biological Process:
- GO:0048675
: axon extension - GO:0030032 : lamellipodium assembly
- GO:0008360 : regulation of cell shape
- GO:0031529 : ruffle organization
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC5 |
|
SRA-1 | Affinity purification-mass spectrometry | Endogenous protein | Rat | Brain | Cerebral cortex lysates | 16025302 | ||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)