Slc1a2 / TRP channels
Name: Excitatory amino acid transporter 2
(Slc1a2)
Official Symbol: SLC1A2
provided by HGNC
Function:
Transports L-glutamate and also L-and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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6506![]() |
P43004![]() |
P43004![]() |
112397![]() |
P43004![]() |
hsa:6506![]() |
600300![]() |
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Mouse
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20511![]() |
P43006![]() |
P43006![]() |
203290![]() |
P43006![]() |
mmu:20511![]() |
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Rat
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29482![]() |
P31596![]() |
P31596![]() |
248124![]() |
P31596![]() |
rno:29482![]() |
PPI pairs:
Biological Process:
- GO:0030534
: adult behavior
- GO:0031668
: cellular response to extracellular stimulus
- GO:0070779
: D-aspartate import
- GO:0051938
: L-glutamate import
- GO:0035264
: multicellular organism growth
- GO:0010259
: multicellular organismal aging
- GO:0046326
: positive regulation of glucose import
- GO:0043200
: response to amino acid stimulus
- GO:0042493
: response to drug
- GO:0009611
: response to wounding
- GO:0007268
: synaptic transmission
- GO:0021537
: telencephalon development
- GO:0007632
: visual behavior
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 |
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Slc1a2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
