Synapsin1 / TRP channels
Name: Synapsin-1
(Synapsin1)
Official Symbol: SYN1
provided by HGNC
Function:
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6853 |
P17600 |
P17600 |
MINT-1370745 |
112719 |
P17600 |
hsa:6853 |
313440 |
||
|
Mouse
|
20964 |
O88935 |
DIP-32198N |
O88935 |
MINT-1531899 |
203600 |
O88935 |
mmu:20964 |
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|
Rat
|
24949 |
P09951 |
DIP-40529N |
P09951 |
MINT-139278 |
247051 |
P09951 |
rno:24949 |
||
Biological Process:
- GO:0008152
: metabolic process - GO:0007269 : neurotransmitter secretion
- GO:0007268 : synaptic transmission
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:313440
:
Epilepsy, X-linked, with variable learning disabilities and behavior disorders
(OMIM:300491 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
Synapsin1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPM7 |
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Synapsin1 | Inference | Prediction | 17088214 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPM7 |
|
Synapsin1 | Co-immunofluorescence staining | Rat SCG sympathetic neuron | 17088214 | |||||
| TRPM7 |
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Synapsin1 | Co-immunoprecipitation | Rat brain synaptic vesicle | 17088214 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)