Syntaxin1a / TRP channels
Name: Syntaxin-1A
(Syntaxin1a)
Official Symbol: STX1A
provided by HGNC
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6804 |
Q16623 |
DIP-390N |
Q16623 |
MINT-255942 |
112676 |
Q16623 |
hsa:6804 |
186590 |
|
Mouse
|
20907 |
O35526 |
O35526 |
MINT-2411610 |
203561 |
O35526 |
mmu:20907 |
|||
Rat
|
116470 |
P32851 |
DIP-108N |
P32851 |
MINT-96097 |
250448 |
P32851 |
rno:116470 |
||
PPI pairs:
Biological Process:
- GO:0017156
: calcium ion-dependent exocytosis - GO:0006112
: energy reserve metabolic process - GO:0014047
: glutamate secretion - GO:0006886
: intracellular protein transport - GO:0007269
: neurotransmitter secretion - GO:0045921
: positive regulation of exocytosis - GO:0001956
: positive regulation of neurotransmitter secretion - GO:0050796
: regulation of insulin secretion - GO:0009629
: response to gravity - GO:0044281
: small molecule metabolic process - GO:0016081
: synaptic vesicle docking involved in exocytosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
Syntaxin1a | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
(
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)







Screening