Syntaxin1a / TRP channels
Name: Syntaxin-1A
(Syntaxin1a)
Official Symbol: STX1A
provided by HGNC
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
![]() |
6804![]() |
Q16623![]() |
DIP-390N![]() |
Q16623![]() |
MINT-255942![]() |
112676![]() |
Q16623![]() |
hsa:6804![]() |
186590![]() |
|
Mouse
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20907![]() |
O35526![]() |
O35526![]() |
MINT-2411610![]() |
203561![]() |
O35526![]() |
mmu:20907![]() |
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Rat
![]() |
116470![]() |
P32851![]() |
DIP-108N![]() |
P32851![]() |
MINT-96097![]() |
250448![]() |
P32851![]() |
rno:116470![]() |
PPI pairs:
Biological Process:
- GO:0017156
: calcium ion-dependent exocytosis
- GO:0006112
: energy reserve metabolic process
- GO:0014047
: glutamate secretion
- GO:0006886
: intracellular protein transport
- GO:0007269
: neurotransmitter secretion
- GO:0045921
: positive regulation of exocytosis
- GO:0001956
: positive regulation of neurotransmitter secretion
- GO:0050796
: regulation of insulin secretion
- GO:0009629
: response to gravity
- GO:0044281
: small molecule metabolic process
- GO:0016081
: synaptic vesicle docking involved in exocytosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 |
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Syntaxin1a | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
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