Syntaxin1a / TRP channels
Name: Syntaxin-1A
(Syntaxin1a)
Official Symbol: STX1A
provided by HGNC
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species | External DB | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6804 | Q16623 | DIP-390N | Q16623 | MINT-255942 | 112676 | Q16623 | hsa:6804 | 186590 | |
Mouse
|
20907 | O35526 | O35526 | MINT-2411610 | 203561 | O35526 | mmu:20907 | |||
Rat
|
116470 | P32851 | DIP-108N | P32851 | MINT-96097 | 250448 | P32851 | rno:116470 |
PPI pairs:
Biological Process:
- GO:0017156 : calcium ion-dependent exocytosis
- GO:0006112 : energy reserve metabolic process
- GO:0014047 : glutamate secretion
- GO:0006886 : intracellular protein transport
- GO:0007269 : neurotransmitter secretion
- GO:0045921 : positive regulation of exocytosis
- GO:0001956 : positive regulation of neurotransmitter secretion
- GO:0050796 : regulation of insulin secretion
- GO:0009629 : response to gravity
- GO:0044281 : small molecule metabolic process
- GO:0016081 : synaptic vesicle docking involved in exocytosis
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top |
Screening | ||||||||||
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 | Syntaxin1a | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(:
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