Syntaxin3 / TRP channels
Name: Syntaxin-3
(Syntaxin3)
Official Symbol: STX3
provided by HGNC
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
6809 |
Q13277 |
DIP-39362N |
Q13277 |
MINT-3027462 |
112678 |
Q13277 |
hsa:6809 |
600876 |
|
|
Mouse
|
20908 |
Q64704 |
MINT-4600034 |
203562 |
Q64704 |
mmu:20908 |
||||
|
Rat
|
81802 |
Q08849 |
MINT-1509039 |
249660 |
Q08849 |
rno:81802 |
||||
Biological Process:
- GO:0006944
: cellular membrane fusion - GO:0034599 : cellular response to oxidative stress
- GO:0006887 : exocytosis
- GO:0006886 : intracellular protein transport
- GO:0031175 : neuron projection development
- GO:0006836 : neurotransmitter transport
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
Syntaxin3 | Inference | Prediction | 15327778 | |||||
| TRPC6 |
|
Syntaxin3 | Inference | Prediction | 15623527 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
Syntaxin3 | Co-immunofluorescence staining | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
Syntaxin3 | Co-immunofluorescence staining | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
Syntaxin3 | Co-immunoprecipitation | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
Syntaxin3 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
Syntaxin3 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC6 |
|
Syntaxin3 | Co-immunoprecipitation | MDCK | 15623527 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)