Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

• GO:0000187 : activation of MAPK activity
• GO:0007250 : activation of NF-kappaB-inducing kinase activity
• GO:0001525 : angiogenesis
• GO:0006915 : apoptotic process
• GO:0038095 : Fc-epsilon receptor signaling pathway
• GO:0043966 : histone H3 acetylation
• GO:0007252 : I-kappaB phosphorylation
• GO:0045087 : innate immune response
• GO:0007254 : JNK cascade
• GO:0002755 : MyD88-dependent toll-like receptor signaling pathway
• GO:2001234 : negative regulation of apoptotic signaling pathway
• GO:0001841 : neural tube formation
• GO:0070423 : nucleotide-binding oligomerization domain containing signaling pathway
• GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB signaling
• GO:0032743 : positive regulation of interleukin-2 production
• GO:0046330 : positive regulation of JNK cascade
• GO:0043507 : positive regulation of JUN kinase activity
• GO:0051092 : positive regulation of NF-kappaB transcription factor activity
• GO:0050870 : positive regulation of T cell activation
• GO:0002726 : positive regulation of T cell cytokine production
• GO:0050852 : T cell receptor signaling pathway
• GO:0034166 : toll-like receptor 10 signaling pathway
• GO:0034134 : toll-like receptor 2 signaling pathway
• GO:0034138 : toll-like receptor 3 signaling pathway
• GO:0034142 : toll-like receptor 4 signaling pathway
• GO:0034146 : toll-like receptor 5 signaling pathway
• GO:0034162 : toll-like receptor 9 signaling pathway
• GO:0038123 : toll-like receptor TLR1
• GO:0038124 : toll-like receptor TLR6
• GO:0006351 : transcription, DNA-templated
• GO:0007179 : transforming growth factor beta receptor signaling pathway
• GO:0035666 : TRIF-dependent toll-like receptor signaling pathway

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/