TAP2 / TRP channels

Name: Antigen peptide transporter 2 (TAP2)
Official Symbol: TAP2 provided by HGNC
Function:
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		6891External Q03519External DIP-322NExternal Q03519External MINT-2838244External 112754External Q03519External   hsa:6891External 170261External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		21355External P36371External     MINT-4136884External 203967External P36371External   mmu:21355External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		24812External P36372External     UNK-5377031External 246934External P36372External   rno:24812External  
PPI pairs:
Biological Process:
  • GO:0002485 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
  • GO:0002489 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
  • GO:0002479 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • GO:0002481 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
  • GO:0046967 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : cytosol to ER transport
  • GO:0019060 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : intracellular transport of viral proteins in host cell
  • GO:0046968 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : peptide antigen transport
  • GO:0002591 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of antigen processing and presentation of peptide antigen via MHC class I
  • GO:0001916 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : positive regulation of T cell mediated cytotoxicity
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TAP2 Affinity purification-mass spectrometry Mouse Not specified Mouse Vascular smooth muscle MOVAS lysates 19879844
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

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