TGS1 / TRP channels
Name: Trimethylguanosine synthase
(TGS1)
Official Symbol: TGS1
provided by HGNC
Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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96764![]() |
Q96RS0![]() |
DIP-49970N![]() |
Q96RS0![]() |
MINT-2878093![]() |
125179![]() |
Q96RS0![]() |
hsa:96764![]() |
606461![]() |
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Mouse
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116940![]() |
Q923W1![]() |
MINT-4611398![]() |
228104![]() |
Q923W1![]() |
mmu:116940![]() |
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Rat
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312947![]() |
P85107![]() |
UNK-6050515![]() |
260282![]() |
P85107![]() |
rno:312947![]() |
PPI pairs:
Biological Process:
- GO:0009452
: 7-methylguanosine RNA capping
- GO:0044255
: cellular lipid metabolic process
- GO:0034660
: ncRNA metabolic process
- GO:0006355
: regulation of transcription, DNA-dependent
- GO:0071167
: ribonucleoprotein complex import into nucleus
- GO:0044281
: small molecule metabolic process
- GO:0000387
: spliceosomal snRNP assembly
- GO:0006351
: transcription, DNA-dependent
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPV1 |
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TGS1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library | 17074976 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
