TPC2 / TRP channels
Name: Two pore calcium channel protein 2
(TPC2)
Official Symbol: TPCN2
provided by HGNC
Function:
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species | External DB | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
219931 | Q8NHX9 | Q8NHX9 | 128596 | Q8NHX9 | 393 | hsa:219931 | 612163 | ||
Mouse
|
233979 | Q8BWC0 | 231481 | Q8BWC0 | mmu:233979 | |||||
Rat
|
309139 | D3ZTJ6 | rno:309139 |
Biological Process:
- GO:0006874 : cellular calcium ion homeostasis
- GO:0051209 : release of sequestered calcium ion into cytosol
- GO:0006939 : smooth muscle contraction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:612163 : Skin/hair/eye pigmentation 10, blond/brown hair (OMIM:612267 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top |
Screening | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPML1 | TPC2 | Inference | Prediction | 21540176 | ||||||
TRPML3 | TPC2 | Inference | Prediction | 21540176 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top |
Validation: In vivo validation | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
TRPML1 | TPC2 | Co-immunofluorescence staining | HEK293T | Human | Full-length | Human | Full-length | 21540176 | ||
TRPML1 | TPC2 | Co-immunofluorescence staining | HeLa | Human | Full-length | Human | Full-length | 21540176 | ||
TRPML1 | TPC2 | Co-immunofluorescence staining | SK-BR-3 | Human | Full-length | Human | Full-length | 21540176 | ||
TRPML1 | TPC2 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 21540176 | ||
TRPML3 | TPC2 | Co-immunofluorescence staining | HEK293T | Human | Full-length | Human | Full-length | 21540176 | ||
TRPML3 | TPC2 | Co-immunofluorescence staining | HeLa | Human | Full-length | Human | Full-length | 21540176 | ||
TRPML3 | TPC2 | Co-immunofluorescence staining | SK-BR-3 | Human | Full-length | Human | Full-length | 21540176 | ||
TRPML3 | TPC2 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 21540176 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)