TRF1 / TRP channels
Name: Telomeric repeat-binding factor 1
(TRF1)
Official Symbol: TERF1
provided by HGNC
Function:
Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
7013 |
P54274 |
DIP-29412N |
P54274 |
MINT-221323 |
112872 |
P54274 |
hsa:7013 |
600951 |
|
|
Mouse
|
21749 |
P70371 |
DIP-44231N |
MINT-3379583 |
204116 |
P70371 |
mmu:21749 |
|||
|
Rat
|
297758 |
Q5EB98 |
UNK-5438152 |
255652 |
Q5EB98 |
rno:297758 |
||||
PPI pairs:
Biological Process:
- GO:0001309
: age-dependent telomere shortening - GO:0051301 : cell division
- GO:0000086 : G2/M transition of mitotic cell cycle
- GO:0006917 : induction of apoptosis
- GO:0007067 : mitosis
- GO:0007094 : mitotic cell cycle spindle assembly checkpoint
- GO:0032214 : negative regulation of telomere maintenance via semi-conservative replication
- GO:0032211 : negative regulation of telomere maintenance via telomerase
- GO:0031116 : positive regulation of microtubule polymerization
- GO:0045840 : positive regulation of mitosis
- GO:0045931 : positive regulation of mitotic cell cycle
- GO:0051260 : protein homooligomerization
- GO:0042493 : response to drug
- GO:0007004 : telomere maintenance via telomerase
- GO:0010834 : telomere maintenance via telomere shortening
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC5 |
|
TRF1 | Affinity purification-mass spectrometry | Not used as a bait | Human | HEK293T | Cell lystaes | 20811636 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)