TRP channels

TRPC
- TRPC1
- TRPC2
- TRPC3
- TRPC4
- TRPC5
- TRPC6
- TRPC7
TRPV
- TRPV1
- TRPV2
- TRPV3
- TRPV4
- TRPV5
- TRPV6
TRPM
- TRPM1
- TRPM2
- TRPM3
- TRPM4
- TRPM5
- TRPM6
- TRPM7
- TRPM8
TRPML
- TRPML1
- TRPML2
- TRPML3
TRPP
- TRPP1
- TRPP2
- TRPP3
TRPA
- TRPA1

» Citation

Nar2011 9c5ccb7544ea9ea0a4b3599ccec8bea610f3995142d5da2da0189fad9f699236

Plos2012 71954aaff6a4569630a779eb6502d687ff86630adfca3a1cc207b9836b808980

Pf2013 33c9f49bb4f61555bed5365c90448ebe56e96eb338f5692f7ef4b8a5db693247

TRPC1 / interactors

At a glance
In detail

Basic Information
External Database
PPI pairs (56)
Biological Process (5)
Disease (0)

Name: Short transient receptor potential channel 1 (TRPC1)

Official Symbol: TRPC1 provided by HGNC

Function:

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species

External DB

Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984

Entrez Gene

UniprotKB

DIP

IntAct

MINT

BioGRID

STRING

IUPHAR-DB

KEGG

OMIM

Human

Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f

Mouse

Rat

PPI pairs:

BMPR-2	Bkca	Calcineurin	Calmodulin	Caspase-1	Caspase-4/Caspase-11	Cav1.2	Caveolin-1
Caveolin-3	Cortactin	D2R	Dystrophin	Enkurin	FGFR-1	FKBP52/FKBP4	Gơq/11
Homer	Homer-1	Homer-2	Homer-3	I-MFA	IP3R2	IP3R3	MARCKS
MGLUR1	MxA	NCS-1	Orai1	Orai2	Orai3	PLCƣ1	PMCA
Protein 4.1	RNF24	RhoA	RyR1	SERCA2	SERCA3	SNAP25	STIM1
STIM2	Src	TRPA1	TRPC3	TRPC4	TRPC5	TRPC6	TRPC7
TRPP1	TRPV4	TRPV6	VAMP	ơ-actinin	ơ-actinin-1	ơ1-syntrophin	Ƣ-tubulin-5

Biological Process:

GO:0007411 : axon guidance
GO:0051480 : cytosolic calcium ion homeostasis
GO:0051281 : positive regulation of release of sequestered calcium ion into cytosol
GO:0051592 : response to calcium ion
GO:0046541 : saliva secretion

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Disease: No information in OMIM

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

top

Screening
			Experimental screening					Non-experimental screening	Reference
			TRP channel construct		Interactor source
TRP channel	Interactor	Method	Species	Region	Species	Organ/tissue	Sample type
TRPC1	BKca	Inference						Prediction	19168436
TRPC1	BMPR-2	Affinity purification-mass spectrometry	Not used as a bait		Mouse	Leg muscle	C2C12 lysates		15188402
TRPC1	Calcineurin	Inference						Prediction	23228564
TRPC1	Calmodulin	Inference						Prediction	11983166
TRPC1	Caspase-1	Speculation						Prediction	24630989
TRPC1	Caspase-4/Caspase-11	Yeast two-hybrid	Not specified		Not specified				24630989
TRPC1	Cav1.2	Inference						Prediction	21672930
TRPC1	Caveolin-1	Inference						Prediction	10766822
TRPC1	Caveolin-3	Inference						Prediction	18544631
TRPC1	Cortactin	Inference						Prediction	19351713
TRPC1	D2R	Yeast two-hybrid	Not used as a bait		Human	Fetal brain	cDNA library		18261457
TRPC1	Dystrophin	Inference						Prediction	17202249
TRPC1	Enkurin	Inference						Prediction	15385169
TRPC1	FGFR-1	Inference						Prediction	15758179
TRPC1	FKBP52/FKBP4	Inference						Prediction	15199065
TRPC1	Gơq/11	Inference						Prediction	10766822
TRPC1	Ƣ-tubulin-5	Affinity purification-mass spectrometry	Human	Full-length	Bovine	Retinal	Tissue lysates		15935109
TRPC1	Ƣ-tubulin-5	Yeast two-hybrid	Human	1-139	Rat	Brain	cDNA library		15935109
TRPC1	Homer-1	Inference						Prediction	14505576
TRPC1	Homer-2	Inference						Prediction	14505576
TRPC1	Homer-3	Inference						Prediction	14505576
TRPC1	I-MFA	Yeast two-hybrid	Human	639-750	Mouse	Embryonic	cDNA library		14530267
TRPC1	I-MFA	Yeast two-hybrid	Human	639-750	Human	Fetal kidney	cDNA library		14530267
TRPC1	IP3R2	Inference						Prediction	10970773
TRPC1	IP3R3	Inference						Prediction	10766822
TRPC1	MARCKS	Inference						Prediction	24022404
TRPC1	MGLUR1	Inference						Prediction	14614461
TRPC1	MxA	Inference						Prediction	15757897
TRPC1	NCS-1	Inference						Prediction	18261457
TRPC1	ơ-actinin	Speculation						Prediction	24146259
TRPC1	ơ-actinin-1	Inference						Prediction	17892531
TRPC1	ơ1-syntrophin	Inference						Prediction	17202249
TRPC1	Orai1	Inference						Prediction	18326500
TRPC1	Orai2	Speculation						Prediction	22640869
TRPC1	Orai3	Speculation						Prediction	22640869
TRPC1	PLCƣ1	Inference						Prediction	15654973
TRPC1	PMCA	Speculation						Prediction	11983166
TRPC1	Protein 4.1	Inference						Prediction	22534489
TRPC1	RhoA	Inference						Prediction	12766172
TRPC1	RNF24	Inference						Prediction	17850865
TRPC1	RyR1	Affinity purification-mass spectrometry	Not used as a bait		Rabbit	Fast-twitch muscle	Triad vesicles		18215135
TRPC1	SERCA2	Inference						Prediction	18068335
TRPC1	SERCA3	Inference						Prediction	18068335
TRPC1	SNAP25	Inference						Prediction	15121806
TRPC1	SRC	Inference						Prediction	16407161
TRPC1	STIM1	Inference						Prediction	16906149
TRPC1	STIM2	Speculation						Prediction	22640869
TRPC1	TRPA1	Inference						Prediction	23994313
TRPC1	TRPC3	Inference						Prediction	9215637
TRPC1	TRPC4	Inference						Prediction	11301024
TRPC1	TRPC5	Inference						Prediction	11301024
TRPC1	TRPC6	Inference						Prediction	12857742
TRPC1	TRPC7	Inference						Prediction	15972814
TRPC1	TRPP1	Inference						Prediction	10097141
TRPC1	TRPV4	Inference						Prediction	20705915
TRPC1	TRPV6	Inference						Prediction	22932896
TRPC1	VAMP	Inference						Prediction	15121806

(

Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

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Validation: In vitro validation
			Assay with recombinant proteins						Reference
			TRP channel construct			Interactor construct
TRP channel	Interactor	Method	Species	Region	Expression system	Species	Region	Expression system
TRPC1	Calmodulin	Fusion protein-pull down assay	Human	649-793	E. coli	Not specified	Full-length	Not specified	11983166
TRPC1	Calmodulin	Fusion protein-pull down assay	Human	1-341	In vitro translation	Not specified	Full-length	E. coli	12601176
TRPC1	Caspase-4/Caspase-11	Fusion protein-pull down assay	Not specified	Full-length	In vitro translation	Not specified	p30 domain	E. coli	24630989
TRPC1	Caveolin-1	Fusion protein-pull down assay	Human	1-347	E. coli	Not specified	Full-length	HSG cell lysates	12732636
TRPC1	Caveolin-1	Yeast two-hybrid	Not specified	317-347	Yeast	Not specified	Full-length	Yeast	19897728
TRPC1	D2R	Fusion protein-pull down assay	Human	638-759	E. coli	Human	131-151	E. coli	18261457
TRPC1	Enkurin	Fusion protein-pull down assay	Human	Full-length	HEK293 lysates	Mouse	Full-length	HEK293 lysates	15385169
TRPC1	Enkurin	Yeast two-hybrid	Human	N-terminus	Yeast	Mouse	Full-length	Yeast	15385169
TRPC1	FKBP52/FKBP4	Co-immunoprecipitation	Human	Full-length	Sf9 lysates	Human	Full-length	Sf9 lysates	15199065
TRPC1	FKBP52/FKBP4	Fusion protein-pull down assay	Human	1-316	HEK293 lysates	Human	Full-length	E. coli	19945390
TRPC1	Homer-3	Fusion protein-pull down assay	Not used		Rat cerebellum lysates	Not specified	Full-length	E. coli	14505576
TRPC1	I-MFA	Fusion protein-pull down assay	Human	639-750	E. coli	Human	Full-length	E. coli	14530267
TRPC1	NCS-1	Fusion protein-pull down assay	Human	639-759	E. coli	Human	Full-length	E. coli	18261457
TRPC1	ơ1-syntrophin	Fusion protein-pull down assay	Not used		C57BL/10 mouse muscle cell lysates	Mouse	75-170	E. coli	19812031
TRPC1	ơ1-syntrophin	Fusion protein-pull down assay	Not used		Mouse myotube lysates	Not specified	75-170	E. coli	17202249
TRPC1	RNF24	Fusion protein-pull down assay	Not specified	3-200	In vitro translation	Human	98-148	E. coli	17850865
TRPC1	SRC	Fusion protein-pull down assay	Mouse	1-341	In vitro translation	Chicken	Full-length	E. coli	16407161
TRPC1	STIM1	Fusion protein-pull down assay	Not specified	1-347	E. coli	Not used		HSG cell lysates	17224452
TRPC1	TRPC3	Fusion protein-pull down assay	Not specified	1-347	E. coli	Not specified	Full-length	HEK293 lysates	15834157
TRPC1	TRPC3	Fusion protein-pull down assay	Not used		Rabbit fast switch muscle lysates	Human	38-381	E. coli	24613381
TRPC1	TRPC3	Yeast two-hybrid	Not specified	1-347	Yeast	Not specified	642-842	Yeast	15834157
TRPC1	TRPP1	Fusion protein-pull down assay	Human	662-750	E. coli	Human	680-968	In vitro translation	10097141

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

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Validation: In vivo validation
			Assay with endogenous proteins	Assay with overexpressed proteins					Reference
			Cell or tissue	Cell or tissue	TRP channel construct		Interactor construct
TRP channel	Interactor	Method	Cell or tissue	Cell or tissue	Species	Region	Species	Region
TRPC1	BKca	Co-immunofluorescence staining	Rat aortic vascular smooth muscle cell						19168436
TRPC1	BKca	Co-immunoprecipitation		HEK293	Human	Full-length	Human	Full-length	19168436
TRPC1	BKca	Co-immunoprecipitation	Rat vascular smooth muscle cell						19168436
TRPC1	Bkca	Co-immunoprecipitation	Porcine coronary artery						25139746
TRPC1	Calcineurin	Co-immunoprecipitation	Human platelets						23228564
TRPC1	Caspase-1	Co-immunoprecipitation		HEK293T	Not specified	Full-length	Not specified	Full-length	24630989
TRPC1	Caspase-4/Caspase-11	Co-immunoprecipitation		HEK293T	Not specified	Full-length	Not specified	Full-length	24630989
TRPC1	Cav1.2	Co-immunoprecipitation	Chick embryonic heart lysates						21672930
TRPC1	Caveolin-1	Co-immunofluorescence staining		HUVEC	Human	Full-length	Mouse	Full-length	20705915
TRPC1	Caveolin-1	Co-immunofluorescence staining	Rat caudal artery section						14551243
TRPC1	Caveolin-1	Co-immunofluorescence staining		HSG cell	Not used		Not specified	Full-length	12732636
TRPC1	Caveolin-1	Co-immunofluorescence staining		HSG cell	Human	Full-length	Not specified	Full-length	12732636
TRPC1	Caveolin-1	Co-immunofluorescence staining		MDCK	Human	Full-length	Not specified	Full-length	12732636
TRPC1	Caveolin-1	Co-immunofluorescence staining	HSG cell						19897728
TRPC1	Caveolin-1	Co-immunoprecipitation	C2C12						19351713
TRPC1	Caveolin-1	Co-immunoprecipitation	Rat caudal artery cell						14551243
TRPC1	Caveolin-1	Co-immunoprecipitation	HSG cell						18430726
TRPC1	Caveolin-1	Co-immunoprecipitation		HSG cell	Human	Full-length	Not used		10766822
TRPC1	Caveolin-1	Co-immunoprecipitation		MDCK	Human	Full-length	Not specified	Full-length	12732636
TRPC1	Caveolin-1	Co-immunoprecipitation	HSG cell						19897728
TRPC1	Caveolin-1	Co-immunoprecipitation		HSG cell	Human	Full-length	Not used		10980191
TRPC1	Caveolin-1	Fluorescence resonance energy transfer		HSG cell	Not specified	Full-length	Not specified	Full-length	19897728
TRPC1	Caveolin-3	Co-immunofluorescence staining	Mouse skeletal muscle section						18544631
TRPC1	Caveolin-3	Co-immunoprecipitation	Mouse skeletal muscle cell						18544631
TRPC1	Caveolin-3	Fluorescence resonance energy transfer		Mouse skeletal muscle	Human	Full-length	Mouse	Full-length	18544631
TRPC1	Cortactin	Co-immunoprecipitation	C2C12						19351713
TRPC1	D2R	Co-immunofluorescence staining	Monkey prefrontal cortex						18261457
TRPC1	D2R	Co-immunoprecipitation	Rat striatal tissue						18261457
TRPC1	D2R	Co-immunoprecipitation	Rat cortex tissue						18261457
TRPC1	Dystrophin	Co-immunofluorescence staining	SolC57						17202249
TRPC1	Dystrophin	Co-immunoprecipitation	Mouse hind limb muscle						17202249
TRPC1	Dystrophin	Co-immunoprecipitation	SolC57						17202249
TRPC1	FGFR-1	Co-immunofluorescence staining	Rat neural stem cell						15758179
TRPC1	FGFR-1	Co-immunoprecipitation	Rat telencephalon						15758179
TRPC1	FKBP52/FKBP4	Co-immunoprecipitation	Rat cerebral cortex						15199065
TRPC1	FKBP52/FKBP4	Co-immunoprecipitation	Human platelets						23228564
TRPC1	FKBP52/FKBP4	Co-immunoprecipitation	MEG-01						23228564
TRPC1	FKBP52/FKBP4	Co-immunoprecipitation		HEK293	Human	Full-length	Not used		19945390
TRPC1	Gơq/11	Co-immunoprecipitation		HSG cell	Human	Full-length	Not used		10766822
TRPC1	Ƣ-tubulin-5	Co-immunofluorescence staining		ARPE-19	Human	Full-length	Not used		15935109
TRPC1	Ƣ-tubulin-5	Co-immunoprecipitation		ARPE-19	Human	Full-length	Not used		15935109
TRPC1	Homer	Co-immunofluorescence staining	Mouse skeletal muscle						18268005
TRPC1	Homer	Co-immunoprecipitation	Mouse skeletal muscle						18268005
TRPC1	Homer-1	Co-immunoprecipitation		HEK293	Human	Full-length	Not used		14505576
TRPC1	Homer-1	Co-immunoprecipitation	Rat brain hippocampus						14505576
TRPC1	Homer-1	Co-immunoprecipitation	Rat astrocyte						16905188
TRPC1	Homer-1	Co-immunoprecipitation	Human platelets						22506990
TRPC1	Homer-2	Co-immunoprecipitation		HEK293	Human	Full-length	Not used		14505576
TRPC1	Homer-3	Co-immunoprecipitation		HEK293	Human	Full-length	Not used		14505576
TRPC1	Homer-3	Co-immunoprecipitation	Rat cerebellum lysates						14505576
TRPC1	Homer-3	Co-immunoprecipitation		HEK293	Human	Full-length	Not used		19945390
TRPC1	I-MFA	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	14530267
TRPC1	I-MFA	Co-immunoprecipitation	Rat liver tissue						14530267
TRPC1	I-MFA	Co-immunoprecipitation	NALM-6						14530267
TRPC1	I-MFA	Co-immunoprecipitation	Rat kidney tissue						14530267
TRPC1	I-MFA	Co-immunoprecipitation		HEK293T	Mouse	Full-length	Mouse	Full-length	23770672
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						11336651
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						18068335
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						16870612
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						18191041
TRPC1	IP3R2	Co-immunoprecipitation	Rat astrocyte						16905188
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						18249094
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						15121806
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						12196544
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						23228564
TRPC1	IP3R2	Co-immunoprecipitation	MEG-01						23228564
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						10970773
TRPC1	IP3R2	Co-immunoprecipitation	Human platelets						17681754
TRPC1	IP3R3	Co-immunofluorescence staining	Human keratinocyte						15654973
TRPC1	IP3R3	Co-immunoprecipitation		HEK293	Human	Full-length	Not used		14505576
TRPC1	IP3R3	Co-immunoprecipitation		HSG cell	Human	Full-length	Not used		10766822
TRPC1	IP3R3	Co-immunoprecipitation		HSG cell	Human	Full-length	Not used		10980191
TRPC1	IP3R3	Co-immunoprecipitation	Human keratinocyte						15654973
TRPC1	MARCKS	Co-immunoprecipitation	Rabbit portal vein tissue lysates						24022404
TRPC1	MGLUR1	Co-immunoprecipitation		CHO	Human	Full-length	Not specified	Not specified	14614461
TRPC1	MGLUR1	Co-immunoprecipitation		HEK293	Human	Full-length	Not specified	Not specified	14614461
TRPC1	MGLUR1	Co-immunoprecipitation	Rat cerebellum lysates						14614461
TRPC1	MxA	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	15757897
TRPC1	ơ-actinin	Co-immunofluorescence staining	Rat ventricular myocytes						24146259
TRPC1	ơ-actinin-1	Co-immunoprecipitation	Human platelets						17892531
TRPC1	ơ1-syntrophin	Co-immunoprecipitation	SolD6						19812031
TRPC1	ơ1-syntrophin	Co-immunoprecipitation	C57BL/10 mouse muscle cell						19812031
TRPC1	ơ1-syntrophin	Co-immunoprecipitation	Mouse muscle lysates						17202249
TRPC1	ơ1-syntrophin	Co-immunoprecipitation		SolC1	Not used		Mouse	Full-length	17202249
TRPC1	ơ1-syntrophin	Co-immunoprecipitation		SolD6	Not used		Mouse	Full-length	17202249
TRPC1	Orai1	Co-immunoprecipitation		HEK293T	Mouse	Full-length	Human	Full-length	23770672
TRPC1	Orai1	Co-immunoprecipitation	HEK293						18326500
TRPC1	Orai1	Co-immunoprecipitation	Human platelets						18644792
TRPC1	Orai1	Co-immunoprecipitation	Human atrial myocyte						23686296
TRPC1	Orai1	Co-immunoprecipitation	Human parathyroid tissue						20194530
TRPC1	Orai2	Co-immunoprecipitation	Human platelets						22640869
TRPC1	Orai3	Co-immunoprecipitation	Human platelets						22640869
TRPC1	PLCƣ1	Co-immunofluorescence staining	Human keratinocyte						15654973
TRPC1	PLCƣ1	Co-immunoprecipitation	Human keratinocyte						15654973
TRPC1	PMCA	Co-immunoprecipitation		HSG cell	Human	Full-length	Not used		11983166
TRPC1	Protein 4.1	Co-immunoprecipitation	Rat pumonary aortic endothelial cell						22534489
TRPC1	RhoA	Co-immunofluorescence staining		Human pulmonary arterial endothelial cell	Not used		Not specified	Full-length	12766172
TRPC1	RhoA	Co-immunoprecipitation	Human pulmonary arterial endothelial cell						12766172
TRPC1	RyR1	Co-immunoprecipitation	Mouse skeletal myotube lysates						18215135
TRPC1	SERCA2	Co-immunoprecipitation	Human platelets						18068335
TRPC1	SERCA2	Co-immunoprecipitation	Human platelets						18191041
TRPC1	SERCA3	Co-immunoprecipitation	Human platelets						18068335
TRPC1	SERCA3	Co-immunoprecipitation	Human platelets						18191041
TRPC1	SNAP25	Co-immunoprecipitation	Human platelets						15121806
TRPC1	STIM1	Co-immunofluorescence staining		HEK293	Human	Full-length	Human	Full-length	16906149
TRPC1	STIM1	Co-immunofluorescence staining	Mouse pulmonary arterial smooth muscle cell						23034388
TRPC1	STIM1	Co-immunofluorescence staining		HSG cell	Human	Full-length	Not specified	Full-length	17224452
TRPC1	STIM1	Co-immunofluorescence staining	HSG cell						19897728
TRPC1	STIM1	Co-immunofluorescence staining	Human saphenous vein vascular smooth muscle cell						18802022
TRPC1	STIM1	Co-immunoprecipitation		HEK293	Human	Full-length	Not used		19228695
TRPC1	STIM1	Co-immunoprecipitation	Human platelets						16870612
TRPC1	STIM1	Co-immunoprecipitation	Mouse pulmonary arterial smooth muscle cell						19332490
TRPC1	STIM1	Co-immunoprecipitation	Rat brain tissue						16906149
TRPC1	STIM1	Co-immunoprecipitation		HEK293	Human	Full-length	Human	Full-length	16906149
TRPC1	STIM1	Co-immunoprecipitation	Mouse pulmonary arterial smooth muscle cell						23034388
TRPC1	STIM1	Co-immunoprecipitation	Human platelets						18249094
TRPC1	STIM1	Co-immunoprecipitation		HEK293	Not specified	Full-length	Human	Full-length	24464579
TRPC1	STIM1	Co-immunoprecipitation	Mouse bone marrow derived macrophages						25013939
TRPC1	STIM1	Co-immunoprecipitation	HEK293						18326500
TRPC1	STIM1	Co-immunoprecipitation	HSG cell						18430726
TRPC1	STIM1	Co-immunoprecipitation		HEK293	Not used		Not specified	Full-length	17224452
TRPC1	STIM1	Co-immunoprecipitation		A7r5	Not used		Not specified	Full-length	17224452
TRPC1	STIM1	Co-immunoprecipitation	Human platelets						18644792
TRPC1	STIM1	Co-immunoprecipitation	HEK293						23395841
TRPC1	STIM1	Co-immunoprecipitation	Human atrial myocyte						23686296
TRPC1	STIM1	Co-immunoprecipitation	HSG cell						19897728
TRPC1	STIM1	Co-immunoprecipitation		HEK293T	Rat	Full-length	Rat	Full-length	22201561
TRPC1	STIM1	Co-immunoprecipitation	Human saphenous vein vascular smooth muscle cell						18802022
TRPC1	STIM1	Co-immunoprecipitation		Human saphenous vein vascular smooth muscle cell	Human	Full-length	Not specified	Full-length	18802022
TRPC1	STIM1	Co-immunoprecipitation	Human platelets						17892531
TRPC1	STIM1	Co-immunoprecipitation	Human parathyroid tissue						20194530
TRPC1	STIM1	Co-immunoprecipitation	SH-SY5Y						22446186
TRPC1	STIM1	Co-immunoprecipitation	HSG cell						20488539
TRPC1	STIM1	Co-immunoprecipitation	Rat normal small intestine cell line IEC-6						22592407
TRPC1	STIM1	Co-immunoprecipitation	Rat normal small intestine cell line IEC-6 (IEC-Cdx2L1 stable cell)						22592407
TRPC1	STIM1	Co-immunoprecipitation	Caco-2 cell						22592407
TRPC1	STIM2	Co-immunoprecipitation	Human platelets						22640869
TRPC1	TRPA1	Co-immunoprecipitation	MEG-01						23994313
TRPC1	TRPC3	Co-immunoprecipitation	HSY cell						15834157
TRPC1	TRPC3	Co-immunoprecipitation	Human platelets						19260825
TRPC1	TRPC3	Co-immunoprecipitation	HEK293						15972814
TRPC1	TRPC3	Co-immunoprecipitation	Rat carotid artery smooth muscle cell						19502552
TRPC1	TRPC3	Co-immunoprecipitation	Mouse skeletal myotube lysates						18215135
TRPC1	TRPC3	Co-immunoprecipitation	Mouse primary skeletal myotubes						24613381
TRPC1	TRPC3	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	9215637
TRPC1	TRPC3	Co-immunoprecipitation	C2C12						21996795
TRPC1	TRPC3	Co-immunoprecipitation		HEK293	Human	Full-length	Human	Full-length	17486119
TRPC1	TRPC3	Co-immunoprecipitation	Rat brain microsome						12857742
TRPC1	TRPC4	Co-immunofluorescence staining	BAE-1						16818374
TRPC1	TRPC4	Co-immunofluorescence staining	Human glomerular mesangial cell						16418302
TRPC1	TRPC4	Co-immunoprecipitation	Rat brain microsome						11301024
TRPC1	TRPC4	Co-immunoprecipitation	BAE-1						16818374
TRPC1	TRPC4	Co-immunoprecipitation	Human glomerular mesangial cell						19307462
TRPC1	TRPC4	Co-immunoprecipitation		HEK293	Human	Full-length	Mouse	Full-length	12032305
TRPC1	TRPC4	Co-immunoprecipitation	C57BL/10 mouse muscle cell						19812031
TRPC1	TRPC4	Co-immunoprecipitation		Sf9	Human	Full-length	Bovine	Full-length	12377790
TRPC1	TRPC4	Co-immunoprecipitation	Rat brain synaptome						12377790
TRPC1	TRPC4	Co-immunoprecipitation	Human platelets						16270640
TRPC1	TRPC4	Co-immunoprecipitation	Mouse lung endothelium cell						17416589
TRPC1	TRPC4	Co-immunoprecipitation	Human glomerular mesangial cell						16418302
TRPC1	TRPC4	Co-immunoprecipitation		Mouse lung endothelial cell	Mouse	Full-length	Mouse	Full-length	22210847
TRPC1	TRPC4	Co-immunoprecipitation	Rat brain microsome						12857742
TRPC1	TRPC4	Co-immunoprecipitation	Human platelets						17892531
TRPC1	TRPC4	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Mouse	Full-length	12032305
TRPC1	TRPC4	Fluorescence resonance energy transfer	Rat pumonary aortic endothelial cell						22534489
TRPC1	TRPC5	Co-immunoprecipitation	Rat brain microsome						11301024
TRPC1	TRPC5	Co-immunoprecipitation		HEK293	Human	Full-length	Mouse	Full-length	11301024
TRPC1	TRPC5	Co-immunoprecipitation		Sf9	Human	Full-length	Mouse	Full-length	12377790
TRPC1	TRPC5	Co-immunoprecipitation	Rat brain synaptome						12377790
TRPC1	TRPC5	Co-immunoprecipitation	Rabbit coronary artery						18356201
TRPC1	TRPC5	Co-immunoprecipitation	Rabbit mesenteric artery						18356201
TRPC1	TRPC5	Co-immunoprecipitation	Rabbit portal vein						18356201
TRPC1	TRPC5	Co-immunoprecipitation	Human platelets						16270640
TRPC1	TRPC5	Co-immunoprecipitation	Mouse vascular smooth muscle cell						21968068
TRPC1	TRPC5	Co-immunoprecipitation	Rat brain microsome						12857742
TRPC1	TRPC5	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Mouse	Full-length	12032305
TRPC1	TRPC6	Co-immunofluorescence staining	Human glomerular mesangial cell						16418302
TRPC1	TRPC6	Co-immunoprecipitation	Human platelets						18191041
TRPC1	TRPC6	Co-immunoprecipitation	Human glomerular mesangial cell						16418302
TRPC1	TRPC6	Co-immunoprecipitation	Rat brain microsome						12857742
TRPC1	TRPC7	Co-immunoprecipitation	HEK293						15972814
TRPC1	TRPP1	Co-immunofluorescence staining		HEK293 tsA 201	Human	Full-length	Human	Full-length	19850920
TRPC1	TRPP1	Co-immunofluorescence staining	mIMCD-3						18323855
TRPC1	TRPP1	Co-immunofluorescence staining		HEK293T	Human	Full-length	Human	Full-length	10097141
TRPC1	TRPP1	Co-immunoprecipitation		HEK293T	Human	Full-length	Not specified	Not specified	14530267
TRPC1	TRPP1	Co-immunoprecipitation		Human glomerular mesangial cell	Human	Full-length	Not used		18256307
TRPC1	TRPP1	Co-immunoprecipitation		HEK293	Mouse	Full-length	Human	Full-length	19812035
TRPC1	TRPP1	Co-immunoprecipitation		HEK293 tsA 201	Human	Full-length	Human	Full-length	19850920
TRPC1	TRPP1	Co-immunoprecipitation	Rat kidney tissue						18323855
TRPC1	TRPP1	Co-immunoprecipitation		HEK293 tsA 201	Human	Full-length	Human	Full-length	20682256
TRPC1	TRPP1	Co-immunoprecipitation		Rat mesenteric artery endothelial cell	Human	Full-length	Human	Full-length	25114176
TRPC1	TRPP1	Co-immunoprecipitation		HEK293	Human	Full-length	Human	Full-length	25114176
TRPC1	TRPP1	Co-immunoprecipitation		HEK293T	Human	Full-length	Human	Full-length	10097141
TRPC1	TRPP1	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Human	Full-length	25114176
TRPC1	TRPV4	Co-immunofluorescence staining		HEK293	Human	Full-length	Mouse	Full-length	20093626
TRPC1	TRPV4	Co-immunofluorescence staining	Rat mesenteric artery endothelial cell lysates						20093626
TRPC1	TRPV4	Co-immunoprecipitation		HEK293	Human	Full-length	Mouse	Full-length	20093626
TRPC1	TRPV4	Co-immunoprecipitation	Rat mesenteric artery endothelial cell lysates						20093626
TRPC1	TRPV4	Co-immunoprecipitation		Rat mesenteric artery endothelial cell	Human	Full-length	Mouse	Full-length	25114176
TRPC1	TRPV4	Co-immunoprecipitation		HEK293	Human	Full-length	Mouse	Full-length	25114176
TRPC1	TRPV4	Co-immunoprecipitation	Porcine coronary artery						25139746
TRPC1	TRPV4	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Mouse	Full-length	20093626
TRPC1	TRPV4	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Mouse	Full-length	20705915
TRPC1	TRPV4	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Mouse	Full-length	21871867
TRPC1	TRPV4	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Mouse	Full-length	25114176
TRPC1	TRPV6	Co-immunoprecipitation		HEK293	Human	Full-length	Rat	Full-length	22932896
TRPC1	TRPV6	Co-immunoprecipitation	LNCaP						25172921
TRPC1	TRPV6	Fluorescence resonance energy transfer		HEK293	Human	Full-length	Rat	Full-length	22932896
TRPC1	VAMP	Co-immunoprecipitation	Human platelets						15121806

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

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Characterization
			Binding region mapping				Stoichiometry	Affinity (Kd)	Reference
			TRP channel		Interactor
TRP channel	Interactor	Method	Species	Region	Species	Region
TRPC1	Calmodulin	Fluorescence probe labeling	Human	720-749	Not specified	Not determined		30 nM	11290752
TRPC1	Calmodulin	Fusion protein-pull down assay	Human	719-751	Not specified	Not determined			11290752
TRPC1	Calmodulin	Fusion protein-pull down assay	Human	719-751	Not specified	Not determined			11983166
TRPC1	Calmodulin	Fusion protein-pull down assay	Human	758-793	Not specified	Not determined			11983166
TRPC1	Caspase-4/Caspase-11	Co-immunoprecipitation	Not specified	1-318	Not specified	p30 domain			24630989
TRPC1	Caveolin-1	Co-immunoprecipitation	Human	781-789	Human	Not determined			16822931
TRPC1	Caveolin-1	Co-immunoprecipitation	Human	781-789	Human	82-101			19052258
TRPC1	Caveolin-1	Fusion protein-pull down assay	Human	Not determined	Human	82-101			16822931
TRPC1	Caveolin-1	Yeast two-hybrid	Human	271-349	Not specified	Not determined			12732636
TRPC1	D2R	Yeast two-hybrid	Human	726-745	Human	131-151			18261457
TRPC1	Homer-3	Co-immunoprecipitation	Human	645-648	Human	EVH1 domain			14505576
TRPC1	Homer-3	Fusion protein-pull down assay	Human	20-23	Not specified	EVH1 domain			14505576
TRPC1	IP3R3	Co-immunoprecipitation	Human	781-789	Human	Not determined			19052258
TRPC1	IP3R3	Co-immunoprecipitation	Human	645-648	Human	Not determined			14505576
TRPC1	IP3R3	Fusion protein-pull down assay	Human	719-751	Human	669-698			11290752
TRPC1	ơ1-syntrophin	Fusion protein-pull down assay	Mouse	Not determined	Not specified	75-170			17202249
TRPC1	ơ1-syntrophin	Fusion protein-pull down assay	Mouse	Not determined	Mouse	75-170			19812031
TRPC1	STIM1	Co-immunoprecipitation	Rat	Not determined	Rat	1798-1887			22201561
TRPC1	STIM1	Co-immunoprecipitation	Human	Not determined	Human	251-535			16906149
TRPC1	STIM1	Fusion protein-pull down assay	Human	1-347	Human	Not determined			17224452
TRPC1	STIM1	Fusion protein-pull down assay	Human	Not determined	Human	251-535			16906149
TRPC1	TRPC3	Yeast two-hybrid	Not specified	1-73	Not specified	1-341			15834157
TRPC1	TRPP1	Atomic force microscopy(AFM) analysis					2:2		19850920
TRPC1	TRPP1	Atomic force microscopy(AFM) analysis					2:2		19193631
TRPC1	TRPP1	Co-immunoprecipitation	Human	Not determined	Human	1-643			10097141
TRPC1	TRPP1	Co-immunoprecipitation	Human	Not determined	Human	679-968			10097141
TRPC1	TRPP1	Yeast two-hybrid	Human	639-750	Human	822-895			10097141
TRPC1	TRPV4	Fluorescence resonance energy transfer					2:2		21871867
TRPC1	TRPV6	Fluorescence resonance energy transfer	Human	1-193	Rat	1-198			22932896

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

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Functional consequence
TRP channel	Interactor	Method	Post-translational modification	Subcellular trafficking	Activity	Reference
TRPC1	Calmodulin	Calcium measurement			Inhibition	11983166
TRPC1	Calmodulin	Patch clamp			Inhibition	11983166
TRPC1	Caveolin-1	Cell surface biotinylation		Increase in plasma membrane level		19897728
TRPC1	D2R	Cell surface biotinylation		Increase in plasma membrane level		18261457
TRPC1	FKBP52/FKBP4	Patch clamp			Inhibition	19945390
TRPC1	Ƣ-tubulin-5	Calcium measurement			Inhibition	15935109
TRPC1	Ƣ-tubulin-5	Co-immunofluorescence staining		Increase in plasma membrane level		15935109
TRPC1	I-MFA	Patch clamp			Inhibition	14530267
TRPC1	I-MFA	Patch clamp			Desensitization	23770672
TRPC1	IP3R2	Calcium measurement			Activation	12196544
TRPC1	IP3R2	Patch clamp			Activation	12196544
TRPC1	MARCKS	Patch clamp			Inhibition	24022404
TRPC1	MGLUR1	Patch clamp			Activation	14614461
TRPC1	PLCƣ1	Calcium measurement			Activation	15654973
TRPC1	STIM1	Patch clamp			Activation	16906149
TRPC1	TRPC3	Patch clamp			New channel creation	10882720
TRPC1	TRPC4	Patch clamp			New channel creation	11301024
TRPC1	TRPC4	Patch clamp			New channel creation	22144671
TRPC1	TRPC5	Patch clamp			New channel creation	11301024
TRPC1	TRPC5	Patch clamp			New channel creation	12857742
TRPC1	TRPP1	Patch clamp			New channel creation	18323855
TRPC1	TRPP1	Patch clamp			New channel creation	25114176
TRPC1	TRPV4	Cell surface biotinylation		Increase in plasma membrane level		20705915
TRPC1	TRPV4	Co-immunofluorescence staining		Increase in plasma membrane level		20705915
TRPC1	TRPV4	Patch clamp			New channel creation	25114176

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

TRIP Database

TRPC1 / interactors