TRPC3 / interactors
- At a glance
- In detail
Name: Short transient receptor potential channel 3
(TRPC3)
Official Symbol: TRPC3
provided by HGNC
Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
7222 |
Q13507 |
DIP-34311N |
Q13507 |
113073 |
Q13507 |
488 |
hsa:7222 |
602345 |
|
|
Mouse
|
22065 |
Q9QZC1 |
204329 |
Q9QZC1 |
mmu:22065 |
|||||
|
Rat
|
60395 |
Q9JMI9 |
DIP-59688N |
248816 |
Q9JMI9 |
rno:60395 |
||||
PPI pairs:
Biological Process:
- GO:0007411
: axon guidance - GO:0007602 : phototransduction
- GO:0030168 : platelet activation
- GO:0010524 : positive regulation of calcium ion transport into cytosol
- GO:0033198 : response to ATP
- GO:0051592 : response to calcium ion
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
14-3-3 protein Ƣ/ơ | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
14-3-3 protein ƥ | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
14-3-3 protein Ƨ | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Aconitase | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
ADT1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
ALDOC | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Annexin 5 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
AP2A2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
AP2B1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
AQP-2 | Inference | Prediction | 17699554 | |||||
| TRPC3 |
|
ATP synthase Ƣ | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Basp1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
BKca | Inference | Prediction | 19052171 | |||||
| TRPC3 |
|
Calmodulin | Inference | Prediction | 11248050 | |||||
| TRPC3 |
|
Calreticulin | Inference | Prediction | 18215135 | |||||
| TRPC3 |
|
Caskin-1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
CaSR | Inference | Prediction | 22778254 | |||||
| TRPC3 |
|
Cav1.2 | Inference | Prediction | 21672930 | |||||
| TRPC3 |
|
Caveolin-1 | Inference | Prediction | 11524429 | |||||
| TRPC3 |
|
Citrate synthase | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Clathrin-H1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Cytochrome c oxidase 2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Cytochrome c oxidase 5A | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
DRP-2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Dynamin-1 heavy chain 1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Dynamin-1L | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Epo-R | Inference | Prediction | 18276585 | |||||
| TRPC3 |
|
Ezrin | Inference | Prediction | 11524429 | |||||
| TRPC3 |
|
Fibronectin | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
FKBP12 | Inference | Prediction | 15199065 | |||||
| TRPC3 |
|
Fumarase | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
GC-A | Inference | Prediction | 22027011 | |||||
| TRPC3 |
|
GLUD1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
GLUT-4 | Inference | Prediction | 17156765 | |||||
| TRPC3 |
|
Gơq | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Gơq/11 | Inference | Prediction | 11524429 | |||||
| TRPC3 |
|
Gz-ơ | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Homer-1 | Inference | Prediction | 16887806 | |||||
| TRPC3 |
|
Idh3B | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
IP3R1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
IP3R1 | Inference | Prediction | 10518223 | |||||
| TRPC3 |
|
IP3R2 | Inference | Prediction | 11290752 | |||||
| TRPC3 |
|
IP3R3 | Inference | Prediction | 10611319 | |||||
| TRPC3 |
|
Junctate | Inference | Prediction | 15302852 | |||||
| TRPC3 |
|
Junctophilin-2 | Inference | Prediction | 18215135 | |||||
| TRPC3 |
|
LETM1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
MAP2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
MDH1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
MDH2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
MG29 | Inference | Prediction | 18215135 | |||||
| TRPC3 |
|
MxA | Inference | Prediction | 15757897 | |||||
| TRPC3 |
|
Myosin-10 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
NCAM1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
NCX1 | Inference | Prediction | 14736881 | |||||
| TRPC3 |
|
Neurofascin | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Neuromodulin | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
NKAơ1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
NKAơ1 | Inference | Prediction | 17012351 | |||||
| TRPC3 |
|
NKAơ2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
NKAơ3 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
ơ-actinin | Speculation | Prediction | 24146259 | |||||
| TRPC3 |
|
Orai1 | Inference | Prediction | 17360584 | |||||
| TRPC3 |
|
Orai2 | Inference | Prediction | 17360584 | |||||
| TRPC3 |
|
Orai3 | Inference | Prediction | 17360584 | |||||
| TRPC3 |
|
ORP-150 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
ơSNAP | Yeast two-hybrid | Human | 1-341 | Rat | Brain | cDNA library | 15327778 | |
| TRPC3 |
|
p97/VCP | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
PDE3A | Inference | Prediction | 21799177 | |||||
| TRPC3 |
|
PEBP1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
PGK1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
PKA | Inference | Prediction | 21799177 | |||||
| TRPC3 |
|
PKCƢ | Inference | Prediction | 20179100 | |||||
| TRPC3 |
|
PKG1 | Inference | Prediction | 14983059 | |||||
| TRPC3 |
|
PLCƢ1 | Inference | Prediction | 11524429 | |||||
| TRPC3 |
|
PLCƣ1 | Inference | Prediction | 12437926 | |||||
| TRPC3 |
|
PLCƣ2 | Inference | Prediction | 12970180 | |||||
| TRPC3 |
|
PLCƢ2 | Inference | Prediction | 15623527 | |||||
| TRPC3 |
|
PLCƢ3 | Inference | Prediction | 15623527 | |||||
| TRPC3 |
|
PMCA | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
PMCA | Speculation | Prediction | 16887806 | |||||
| TRPC3 |
|
PMCA2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
PMCA3 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
PMCA4 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Pyruvate kinase M1/M2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
RACK1 | Yeast two-hybrid | Not specified | 1-341 | Human | Embroynic kidney | cDNA library | 18755685 | |
| TRPC3 |
|
RAP1A | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
RAP1B | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
RNF24 | Inference | Prediction | 17850865 | |||||
| TRPC3 |
|
RyR | Inference | Prediction | 10983988 | |||||
| TRPC3 |
|
RyR2 | Inference | Prediction | 17012351 | |||||
| TRPC3 |
|
SERCA2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
SERCA2 | Inference | Prediction | 11524429 | |||||
| TRPC3 |
|
Slc1a2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Slc1a3 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
SNAP23 | Inference | Prediction | 15327778 | |||||
| TRPC3 |
|
SNAP25 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
SOD2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
SRC | Inference | Prediction | 16407161 | |||||
| TRPC3 |
|
STIM1 | Speculation | Prediction | 22640869 | |||||
| TRPC3 |
|
STIM2 | Speculation | Prediction | 22640869 | |||||
| TRPC3 |
|
SV2A | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Synapsin1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Synaptotagmin 1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Syntaxin1a | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
Syntaxin3 | Inference | Prediction | 15327778 | |||||
| TRPC3 |
|
Tenascin-R | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
TrkB | Inference | Prediction | 10677043 | |||||
| TRPC3 |
|
TRPC1 | Inference | Prediction | 9215637 | |||||
| TRPC3 |
|
TRPC4 | Inference | Prediction | 16537542 | |||||
| TRPC3 |
|
TRPC5 | Inference | Prediction | 12857742 | |||||
| TRPC3 |
|
TRPC6 | Inference | Prediction | 12032305 | |||||
| TRPC3 |
|
TRPC7 | Inference | Prediction | 12032305 | |||||
| TRPC3 |
|
TRPM4 | Yeast two-hybrid | Not used as a bait | Human | Brain | cDNA library | 18262493 | ||
| TRPC3 |
|
TRPP1 | Inference | Prediction | 19812035 | |||||
| TRPC3 |
|
UCH-L1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
VAMP2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
VAMP2 | Yeast two-hybrid | Human | 1-341 | Rat | Brain | cDNA library | 15327778 | |
| TRPC3 |
|
VAT2 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
VDAC1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
VDAC3 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
| TRPC3 |
|
WNK4 | Inference | Prediction | 21670282 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vitro validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with recombinant proteins | Reference | |||||||||
| TRP channel construct | Interactor construct | |||||||||
| TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
| TRPC3 |
|
BKca | Fusion protein-pull down assay | Not used | Mouse podocyte lysates | Chicken | Full-length | E. coli | 19052171 | |
| TRPC3 |
|
Calmodulin | Fusion protein-pull down assay | Human | 1-340 | In vitro translation | Not specified | Full-length | E. coli | 12601176 |
| TRPC3 |
|
Calmodulin | Fusion protein-pull down assay | Human | 742-795 | E. coli | Rat | Full-length | In vitro translation | 11248050 |
| TRPC3 |
|
FKBP12 | Co-immunoprecipitation | Human | Full-length | Sf9 lysates | Human | Full-length | Sf9 lysates | 15199065 |
| TRPC3 |
|
Homer-1 | Fusion protein-pull down assay | Human | Full-length | HEK293 lysates | Human | Full-length | E. coli | 16887806 |
| TRPC3 |
|
IP3R3 | Fusion protein-pull down assay | Human | 676-848 | In vitro translation | Human | 638-926 | E. coli | 10611319 |
| TRPC3 |
|
Junctate | Fusion protein-pull down assay | Bovine | Full-length | HEK293 lysates | Not specified | 1-85 | Not specified | 15302852 |
| TRPC3 |
|
Junctophilin-2 | Fusion protein-pull down assay | Not used | Rabbit back and leg fast-twich skeletal muscle lysates | Mouse | Full-length | E. coli | 19277847 | |
| TRPC3 |
|
MxA | Fusion protein-pull down assay | Human | 1-201 | In vitro translation | Human | 572-662 | E. coli | 15757897 |
| TRPC3 |
|
NCX1 | Fusion protein-pull down assay | Human | 742-848 | E. coli | Not used | HEK293 lysates | 14736881 | |
| TRPC3 |
|
NCX1 | Fusion protein-pull down assay | Human | 670-848 | E. coli | Not used | Rat Cardiomyocyte lysates | 17129578 | |
| TRPC3 |
|
Orai1 | Fusion protein-pull down assay | Human | 1-340 | In vitro translation | Human | Full-length | E. coli | 17360584 |
| TRPC3 |
|
Orai1 | Fusion protein-pull down assay | Human | 676-848 | In vitro translation | Human | Full-length | E. coli | 17360584 |
| TRPC3 |
|
PKCƢ | Fusion protein-pull down assay | Mouse | 659-836 | E. coli | Not used | DT40 lysates | 20179100 | |
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-340 | Yeast | Rat | 750-1290 | Yeast | 12437926 |
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-171 | Yeast | Rat | 796-920 | Yeast | 15744307 |
| TRPC3 |
|
RNF24 | Fusion protein-pull down assay | Not specified | 1-201 | In vitro translation | Human | 98-148 | E. coli | 17850865 |
| TRPC3 |
|
SRC | Fusion protein-pull down assay | Mouse | 1-340 | In vitro translation | Chicken | Full-length | E. coli | 16407161 |
| TRPC3 |
|
TRPC1 | Fusion protein-pull down assay | Not specified | Full-length | HEK293 lysates | Not specified | 1-347 | E. coli | 15834157 |
| TRPC3 |
|
TRPC1 | Fusion protein-pull down assay | Human | 38-381 | E. coli | Not used | Rabbit fast switch muscle lysates | 24613381 | |
| TRPC3 |
|
TRPC1 | Yeast two-hybrid | Not specified | 642-842 | Yeast | Not specified | 642-842 | Yeast | 15834157 |
| TRPC3 |
|
TRPM4 | Yeast two-hybrid | Human | Full-length | Yeast | Human | Full-length | Yeast | 18262493 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
ADT1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
AQP-2 | Co-immunofluorescence staining | Rat kidney medullary collecting duct | 20107112 | |||||
| TRPC3 |
|
AQP-2 | Co-immunofluorescence staining | Rat kidney duct section | 17699554 | |||||
| TRPC3 |
|
AQP-2 | Co-immunoprecipitation | mIMCD-3 | 17699554 | |||||
| TRPC3 |
|
AQP-2 | Co-immunoprecipitation | Rat medulla lysates | 17699554 | |||||
| TRPC3 |
|
BKca | Co-immunofluorescence staining | HEK293T | Not specified | Full-length | Not specified | Full-length | 19052171 | |
| TRPC3 |
|
BKca | Co-immunoprecipitation | Mouse podocyte lysates | 19052171 | |||||
| TRPC3 |
|
BKca | Co-immunoprecipitation | HEK293T | Not specified | Full-length | Not specified | Full-length | 19052171 | |
| TRPC3 |
|
Calmodulin | Co-immunoprecipitation | Mouse skeletal myotube lysates | 18215135 | |||||
| TRPC3 |
|
Calreticulin | Co-immunoprecipitation | Mouse skeletal myotube lysates | 18215135 | |||||
| TRPC3 |
|
CaSR | Co-immunofluorescence staining | Mouse submandibular gland (SMG) ductal tissue section | 22778254 | |||||
| TRPC3 |
|
CaSR | Co-immunoprecipitation | Mouse submandibular gland (SMG) ductal cell lysates | 22778254 | |||||
| TRPC3 |
|
Cav1.2 | Co-immunoprecipitation | Chick embryonic heart lysates | 21672930 | |||||
| TRPC3 |
|
Caveolin-1 | Co-immunofluorescence staining | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
Caveolin-1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
Clathrin-H1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
DRP-2 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
Dynamin-1 heavy chain 1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
Epo-R | Co-immunofluorescence staining | HEK293T | Human | Full-length | Human | Full-length | 19074769 | |
| TRPC3 |
|
Epo-R | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 21757714 | |
| TRPC3 |
|
Epo-R | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 18276585 | |
| TRPC3 |
|
Epo-R | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 19074769 | |
| TRPC3 |
|
Epo-R | Co-immunoprecipitation | TF-1 | 19074769 | |||||
| TRPC3 |
|
Ezrin | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
FKBP12 | Co-immunoprecipitation | Rat cerebral cortex | 15199065 | |||||
| TRPC3 |
|
GC-A | Co-immunoprecipitation | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011 | |
| TRPC3 |
|
GC-A | Co-immunoprecipitation | Mouse cardiac myocyte lysates | Not used | Rat | Full-length | 22027011 | ||
| TRPC3 |
|
GC-A | Fluorescence resonance energy transfer | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011 | |
| TRPC3 |
|
GLUT-4 | Co-immunoprecipitation | Mouse cardiomyocytes | 17156765 | |||||
| TRPC3 |
|
Gơq/11 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
Gơq/11 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
Gz-ơ | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
Homer | Co-immunoprecipitation | Mouse skeletal myotube lysates | 18215135 | |||||
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | Rat cerebral arterial lysates | 20378853 | |||||
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | Rat mesenteric artery lysates | 23045459 | |||||
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Rat | Full-length | 10518223 | |
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | HEK293 | 20022948 | |||||
| TRPC3 |
|
IP3R2 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
IP3R2 | Co-immunoprecipitation | Sheep uterine arterial endothelial cell | 16899571 | |||||
| TRPC3 |
|
IP3R3 | Co-immunofluorescence staining | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
IP3R3 | Co-immunofluorescence staining | Mouse pancreatic acini | 16887806 | |||||
| TRPC3 |
|
IP3R3 | Co-immunofluorescence staining | Mouse parotid acini | 16887806 | |||||
| TRPC3 |
|
IP3R3 | Co-immunofluorescence staining | Mouse submandibular gland duct | 16887806 | |||||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 14505576 | ||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | Mouse brain tissue | 16887806 | |||||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | Mouse pancreatic tissue | 16887806 | |||||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | Mouse submandibular gland lysates | 16887806 | |||||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 10611319 | |
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 10983988 | ||
| TRPC3 |
|
Junctophilin-2 | Co-immunoprecipitation | Mouse skeletal muscle myoblast lysates | Not used | Mouse | Full-length | 20095964 | ||
| TRPC3 |
|
Junctophilin-2 | Co-immunoprecipitation | Mouse skeletal myotube lysates | 18215135 | |||||
| TRPC3 |
|
MG29 | Co-immunoprecipitation | Mouse skeletal myotube lysates | 18215135 | |||||
| TRPC3 |
|
MxA | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 15757897 | |
| TRPC3 |
|
NCX1 | Co-immunofluorescence staining | Rat myocyte section | 17012351 | |||||
| TRPC3 |
|
NCX1 | Co-immunofluorescence staining | Rat cardiomyocytes | 17129578 | |||||
| TRPC3 |
|
NCX1 | Co-immunofluorescence staining | dnTRPC3 TG mouse heart myocyte | 20351294 | |||||
| TRPC3 |
|
NCX1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 14736881 | ||
| TRPC3 |
|
NCX1 | Co-immunoprecipitation | Sf9 | Mouse | Not specified | Rat | Not specified | 17012351 | |
| TRPC3 |
|
NCX1 | Co-immunoprecipitation | Rat ventricle lysates | 17012351 | |||||
| TRPC3 |
|
NCX1 | Co-immunoprecipitation | Rat cardiomyocytes | 17129578 | |||||
| TRPC3 |
|
Neuromodulin | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
NKAơ1 | Co-immunofluorescence staining | Rat myocyte section | 17012351 | |||||
| TRPC3 |
|
NKAơ1 | Co-immunoprecipitation | Rat ventricle lysates | 17012351 | |||||
| TRPC3 |
|
NKAơ1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
ơ-actinin | Co-immunofluorescence staining | Rat ventricular myocytes | 24146259 | |||||
| TRPC3 |
|
Orai1 | Co-immunoprecipitation | COS-7 | Human | Full-length | Human | Full-length | 17360584 | |
| TRPC3 |
|
Orai1 | Co-immunoprecipitation | HEK293 | 20022948 | |||||
| TRPC3 |
|
Orai2 | Co-immunoprecipitation | Human platelets | 22640869 | |||||
| TRPC3 |
|
Orai2 | Co-immunoprecipitation | COS-7 | Human | Full-length | Human | Full-length | 17360584 | |
| TRPC3 |
|
Orai3 | Co-immunoprecipitation | Human platelets | 22640869 | |||||
| TRPC3 |
|
Orai3 | Co-immunoprecipitation | COS-7 | Human | Full-length | Human | Full-length | 17360584 | |
| TRPC3 |
|
ơSNAP | Co-immunofluorescence staining | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
ơSNAP | Co-immunofluorescence staining | HSG cell | 15327778 | |||||
| TRPC3 |
|
ơSNAP | Co-immunofluorescence staining | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
ơSNAP | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
PDE3A | Co-immunoprecipitation | HEK293 | Not specified | Full-length | Not used | 21799177 | ||
| TRPC3 |
|
PKA | Co-immunoprecipitation | HEK293 | Not specified | Full-length | Not used | 21799177 | ||
| TRPC3 |
|
PKCƢ | Co-immunoprecipitation | DT40 | 20179100 | |||||
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Human | Full-length | 19289841 | |
| TRPC3 |
|
PLCƢ1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 21757714 | |
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | Human erythroid cell | 18276585 | |||||
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 18276585 | |
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 12437926 | |
| TRPC3 |
|
PLCƢ1 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
PLCƣ1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Rat | Full-length | 19074769 | |
| TRPC3 |
|
PLCƣ2 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Chicken | Full-length | 12970180 | |
| TRPC3 |
|
PLCƣ2 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Rat | Full-length | 19289841 | |
| TRPC3 |
|
PLCƢ2 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
PLCƣ2 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Chicken | Full-length | 20179100 | |
| TRPC3 |
|
PLCƢ3 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
PMCA | Co-immunoprecipitation | Mouse brain tissue | 16887806 | |||||
| TRPC3 |
|
PMCA | Co-immunoprecipitation | Mouse pancreatic tissue | 16887806 | |||||
| TRPC3 |
|
PMCA | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
RACK1 | Co-immunofluorescence staining | HEK293 | Not specified | Full-length | Not used | 18755685 | ||
| TRPC3 |
|
RACK1 | Co-immunoprecipitation | HEK293 | Not specified | Full-length | Not used | 18755685 | ||
| TRPC3 |
|
RACK1 | Co-immunoprecipitation | Rat brain lysates | 18755685 | |||||
| TRPC3 |
|
RNF24 | Co-immunofluorescence staining | HEK293 | Not specified | Full-length | Human | Full-length | 17850865 | |
| TRPC3 |
|
RyR | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 10983988 | ||
| TRPC3 |
|
RyR2 | Co-immunofluorescence staining | Rat myocyte section | 17012351 | |||||
| TRPC3 |
|
RyR2 | Co-immunoprecipitation | Rat ventricle lysates | 17012351 | |||||
| TRPC3 |
|
SERCA2 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 11524429 | ||
| TRPC3 |
|
SERCA2 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
SNAP23 | Co-immunofluorescence staining | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
SNAP23 | Co-immunofluorescence staining | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
SNAP23 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
SRC | Co-immunoprecipitation | COS-7 | Mouse | Full-length | Chicken | Full-length | 16407161 | |
| TRPC3 |
|
STIM1 | Co-immunoprecipitation | Human platelets | 22640869 | |||||
| TRPC3 |
|
STIM1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | Full-length | 23068106 | |
| TRPC3 |
|
STIM1 | Co-immunoprecipitation | Not specified | Full-length (mutant) | Human | Full-length | 24464579 | ||
| TRPC3 |
|
STIM2 | Co-immunoprecipitation | Human platelets | 22640869 | |||||
| TRPC3 |
|
Synaptotagmin 1 | Co-immunoprecipitation | Rat brain lysates | 18205297 | |||||
| TRPC3 |
|
Syntaxin3 | Co-immunofluorescence staining | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
Syntaxin3 | Co-immunofluorescence staining | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
Syntaxin3 | Co-immunoprecipitation | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
Syntaxin3 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
Syntaxin3 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
TrkB | Co-immunofluorescence staining | Rat brain pontine neuron | 10677043 | |||||
| TRPC3 |
|
TrkB | Co-immunoprecipitation | Rat brain lysates | 10677043 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | HSY cell | 15834157 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | Human platelets | 19260825 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | HEK293 | 15972814 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | Rat carotid artery smooth muscle cell | 19502552 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | Mouse skeletal myotube lysates | 18215135 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | Mouse primary skeletal myotubes | 24613381 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 9215637 | |
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | C2C12 | 21996795 | |||||
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | Full-length | 17486119 | |
| TRPC3 |
|
TRPC1 | Co-immunoprecipitation | Rat brain microsome | 12857742 | |||||
| TRPC3 |
|
TRPC4 | Co-immunofluorescence staining | Porcine primary aortic endothelial cell | 16537542 | |||||
| TRPC3 |
|
TRPC4 | Co-immunoprecipitation | Rat brain microsome | 12857742 | |||||
| TRPC3 |
|
TRPC4 | Co-immunoprecipitation | HEK293 | Human | Full-length | Mouse | Full-length | 16537542 | |
| TRPC3 |
|
TRPC4 | Co-immunoprecipitation | Porcine primary aortic endothelial cell | 16537542 | |||||
| TRPC3 |
|
TRPC4 | Co-immunoprecipitation | TRPC3 dnTRPC4 DTG mouse heart lysataes | 20351294 | |||||
| TRPC3 |
|
TRPC5 | Co-immunoprecipitation | Rat brain microsome | 12857742 | |||||
| TRPC3 |
|
TRPC6 | Co-immunofluorescence staining | MDA-MB-231 | 19689790 | |||||
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | dnTRPC6 Neonatal rat ventricular myocytes | 20351294 | |||||
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | Human platelets | 19260825 | |||||
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | MDA-MB-231 | 19689790 | |||||
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | Full-length | 12032305 | |
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | Rat brain synaptome | 12377790 | |||||
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | Sf9 | Human | Full-length | Mouse | Full-length | 12377790 | |
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | Human platelets | 16270640 | |||||
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | MDCK | Not specified | Full-length | Not used | 15623527 | ||
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 19074769 | |
| TRPC3 |
|
TRPC6 | Co-immunoprecipitation | TF-1 | 19074769 | |||||
| TRPC3 |
|
TRPC6 | Fluorescence resonance energy transfer | HEK293 | Human | Full-length | Human | Full-length | 12032305 | |
| TRPC3 |
|
TRPC7 | Co-immunoprecipitation | Sf9 | Human | Full-length | Mouse | Full-length | 12377790 | |
| TRPC3 |
|
TRPC7 | Co-immunoprecipitation | Rat brain synaptome | 12377790 | |||||
| TRPC3 |
|
TRPC7 | Co-immunoprecipitation | Rat ventricular myocytes | 18502908 | |||||
| TRPC3 |
|
TRPC7 | Co-immunoprecipitation | CHO | Human | Full-length | Mouse | 1-494 | 15537648 | |
| TRPC3 |
|
TRPC7 | Fluorescence resonance energy transfer | HEK293 | Human | Full-length | Mouse | Full-length | 12032305 | |
| TRPC3 |
|
TRPM4 | Co-immunofluorescence staining | HEK293T | Human | Full-length | Human | Full-length | 18262493 | |
| TRPC3 |
|
TRPM4 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 18262493 | |
| TRPC3 |
|
TRPP1 | Co-immunofluorescence staining | LLC-PK1 | Not used | Human | 1-697 | 19812035 | ||
| TRPC3 |
|
TRPP1 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Human | 1-697 | 19812035 | |
| TRPC3 |
|
VAMP2 | Co-immunofluorescence staining | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
VAMP2 | Co-immunofluorescence staining | HSG cell | 15327778 | |||||
| TRPC3 |
|
VAMP2 | Co-immunofluorescence staining | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
VAMP2 | Co-immunoprecipitation | Rat hippocampal neuron | 15327778 | |||||
| TRPC3 |
|
VAMP2 | Co-immunoprecipitation | HEK293 | Human | Full-length | Not used | 15327778 | ||
| TRPC3 |
|
WNK4 | Co-immunoprecipitation | Rat aorta lysates | 21670282 | |||||
| TRPC3 |
|
WNK4 | Co-immunoprecipitation | HEK293T | Human | Full-length | Mouse | Full-length | 21670282 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Characterization
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
| TRP channel | Interactor | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPC3 |
|
Calmodulin | Fluorescence probe labeling | Human | 764-793 | Bovine | Not determined | 100 nM | 11248050 | |
| TRPC3 |
|
Calmodulin | Fluorescence probe labeling | Human | 764-793 | Not specified | Not determined | 100 nM | 11290752 | |
| TRPC3 |
|
Calmodulin | Fusion protein-pull down assay | Human | 761-795 | Not specified | Not determined | 11290752 | ||
| TRPC3 |
|
Epo-R | Co-immunoprecipitation | Human | 671-746 | Human | Not determined | 19074769 | ||
| TRPC3 |
|
IP3R1 | Co-immunoprecipitation | Human | Not determined | Rat | IP3 binding domain | 10518223 | ||
| TRPC3 |
|
IP3R1 | Fusion protein-pull down assay | Mouse | 725-848 | Not specified | 654-688 | 11290752 | ||
| TRPC3 |
|
IP3R2 | Fusion protein-pull down assay | Mouse | 725-848 | Not specified | 675-695 | 11290752 | ||
| TRPC3 |
|
IP3R3 | Co-immunoprecipitation | Human | 775-787 | Rat | Not determined | 18276585 | ||
| TRPC3 |
|
IP3R3 | Fusion protein-pull down assay | Human | 761-795 | Human | 669-698 | 11248050 | ||
| TRPC3 |
|
IP3R3 | Fusion protein-pull down assay | Human | 761-795 | Human | 669-698 | 11290752 | ||
| TRPC3 |
|
IP3R3 | Fusion protein-pull down assay | Mouse | 725-848 | Human | 681-698 | 11290752 | ||
| TRPC3 |
|
IP3R3 | Fusion protein-pull down assay | Human | 777-797 | Human | 669-698 | 10611319 | ||
| TRPC3 |
|
IP3R3 | Fusion protein-pull down assay | Human | 777-797 | Human | 751-821 | 10611319 | ||
| TRPC3 |
|
Junctophilin-2 | Fusion protein-pull down assay | Mouse | Not determined | Mouse | 143-234 | 19277847 | ||
| TRPC3 |
|
MxA | Fusion protein-pull down assay | Human | 1-201 | Human | 572-662 | 15757897 | ||
| TRPC3 |
|
NCX1 | Fusion protein-pull down assay | Human | 670-848 | Rat | Not determined | 17129578 | ||
| TRPC3 |
|
PKCƢ | Fusion protein-pull down assay | Mouse | 659-836 | Chicken | Not determined | 20179100 | ||
| TRPC3 |
|
PLCƣ1 | Fusion protein-pull down assay | Human | 1-52 | Rat | 794-933 | 16500902 | ||
| TRPC3 |
|
PLCƣ1 | Fusion protein-pull down assay | Human | 40-48 | Rat | 861-920 | 15744307 | ||
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 40-46 | Rat | 861-920 | 15744307 | ||
| TRPC3 |
|
PLCƣ1 | Yeast two-hybrid | Human | 1-340 | Rat | 780-920 | 12437926 | ||
| TRPC3 |
|
PLCƣ2 | Co-immunoprecipitation | Mouse | Not determined | Chicken | 810-829 | 12970180 | ||
| TRPC3 |
|
RACK1 | Yeast two-hybrid | Not specified | 221-342 | Human | Not determined | 18755685 | ||
| TRPC3 |
|
SRC | Co-immunoprecipitation | Mouse | 1-370 | Chicken | SH2 domain | 16407161 | ||
| TRPC3 |
|
TRPC1 | Yeast two-hybrid | Not specified | 1-341 | Not specified | 1-73 | 15834157 | ||
| TRPC3 |
|
TRPM4 | Co-immunoprecipitation | Human | Not determined | Human | 858-1188 | 18262493 | ||
| TRPC3 |
|
TRPP1 | Fusion protein-pull down assay | Mouse | 659-753 | Human | 1-697 | 19812035 | ||
| TRPC3 |
|
VAMP2 | Yeast two-hybrid | Human | 1-123 | Rat | Not determined | 15327778 | ||
| TRPC3 |
|
WNK4 | Co-immunoprecipitation | Human | 1-196 | Mouse | 441-799 | 21670282 | ||
| TRPC3 |
|
WNK4 | Co-immunoprecipitation | Human | 1-196 | Mouse | 441-1032 | 21670282 | ||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
| TRPC3 |
|
Calmodulin | Patch clamp | Inhibition | 11248050 | |||||||
| TRPC3 |
|
CaSR | Cell surface biotinylation | Increase in plasma membrane level | 22778254 | |||||||
| TRPC3 |
|
Epo-R | Calcium measurement | Activation | 18276585 | |||||||
| TRPC3 |
|
Epo-R | Patch clamp | Activation | 18276585 | |||||||
| TRPC3 |
|
Homer-1 | Cell surface biotinylation | Increase in plasma membrane level | 16887806 | |||||||
| TRPC3 |
|
Homer-1 | Patch clamp | Activation | 16887806 | |||||||
| TRPC3 |
|
IP3R1 | Calcium measurement | Activation | 10518223 | |||||||
| TRPC3 |
|
IP3R1 | Patch clamp | Activation | 10518223 | |||||||
| TRPC3 |
|
IP3R3 | Calcium measurement | Activation | 10611319 | |||||||
| TRPC3 |
|
IP3R3 | Calcium measurement | Inhibition | 10611319 | |||||||
| TRPC3 |
|
IP3R3 | Patch clamp | Activation | 11248050 | |||||||
| TRPC3 |
|
Junctate | Patch clamp | Activation | 15302852 | |||||||
| TRPC3 |
|
Orai1 | Patch clamp | Activation | 18287061 | |||||||
| TRPC3 |
|
PKG1 | In vitro PTM assay | Phosphorylation (Tyr-11) | 14983059 | |||||||
| TRPC3 |
|
PKG1 | In vitro PTM assay | Phosphorylation (Ser-263) | 14983059 | |||||||
| TRPC3 |
|
PLCƣ1 | Calcium measurement | Activation | 12437926 | |||||||
| TRPC3 |
|
PLCƣ1 | Calcium measurement | Activation | 15744307 | |||||||
| TRPC3 |
|
PLCƣ2 | Calcium measurement | Activation | 12970180 | |||||||
| TRPC3 |
|
PLCƣ2 | Patch clamp | Activation | 12970180 | |||||||
| TRPC3 |
|
RNF24 | Cell surface biotinylation | Decrease in plasma membrane level | 17850865 | |||||||
| TRPC3 |
|
RyR | Patch clamp | Activation | 10983988 | |||||||
| TRPC3 |
|
SRC | Calcium measurement | Activation | 16407161 | |||||||
| TRPC3 |
|
SRC | In vivo PTM assay | Phosphorylation (Tyr-226) | 16407161 | |||||||
| TRPC3 |
|
TRPC1 | Patch clamp | New channel creation | 10882720 | |||||||
| TRPC3 |
|
TRPM4 | Patch clamp | Inhibition | 18262493 | |||||||
| TRPC3 |
|
TRPP1 | Calcium measurement | Activation | 19812035 | |||||||
| TRPC3 |
|
WNK4 | Cell surface biotinylation | Decrease in plasma membrane level | 21670282 | |||||||
| TRPC3 |
|
WNK4 | Ion influx measurement | Inhibition | 21670282 | |||||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)