TRPML1 / interactors

Name: Mucolipin-1 (TRPML1)
Official Symbol: MCOLN1 provided by HGNC
Function:
Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
57192External Q9GZU1External   Q9GZU1External MINT-1409368External 121441External Q9GZU1External 501External hsa:57192External 605248External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
94178External Q99J21External       220458External Q99J21External   mmu:94178External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f
288371External D3ZRF9External       252540External     rno:288371External  
Biological Process:
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ALG-2/PDCD6 Affinity purification-mass spectrometry Human 1-66 HeLa lysates 19864416
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Cdc42 Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ERIGC3 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Mouse Heart cDNA library 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HOP/STI1 Inference Prediction 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSC70 Yeast two-hybrid Human 94-298 Human Brain cDNA library 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP40/DNAJB1 Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP40/DNAJC14 Yeast two-hybrid Human 94-298 Human Brain cDNA library 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP90 Inference Prediction 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4a Yeast two-hybrid Human Full-length Human adult brain cDNA library 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4b Yeast two-hybrid Human Full-length Human adult brain cDNA library 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM5 Speculation Prediction 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NDKA Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NovelProtein/NP9 Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PEA-15 Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Peroxisomal membrane protein 2 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Mouse Heart cDNA library 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PEX16 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Mouse Heart cDNA library 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PIP5K1A Split-Ubiquitin Yeast two-hybrid Mouse Full-length Mouse Heart cDNA library 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKA Inference Prediction 17988215
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Rac1 Speculation Prediction 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Rac2 Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RFP/TRIM27 Yeast two-hybrid Human Full-length Human Fetal brain cDNA library 16169070
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RhoG Speculation Prediction 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SEC13 Affinity purification-mass spectrometry Human 1-66 HeLa lysates 19864416
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SEC31A Affinity purification-mass spectrometry Human 1-66 HeLa lysates 19864416
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SLC35E1 Yeast two-hybrid Human Full-length Human Fetal brain cDNA library 16169070
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 STOML1 Affinity purification-mass spectrometry Mouse Full-length Mouse RAW264.7 macrophages Lysates 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TMEM163 Yeast two-hybrid Mouse Full-length Mouse Kidney cDNA library 25130899
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC1 Inference Prediction 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC2 Inference Prediction 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Inference Prediction 16606612
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Inference Prediction 16606612
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Unnamed protein (BAE) Split-Ubiquitin Yeast two-hybrid Mouse Full-length Mouse Heart cDNA library 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 YIF1B Split-Ubiquitin Yeast two-hybrid Mouse Full-length Mouse Heart cDNA library 23418601
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vitro validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with recombinant proteins Reference
TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Expression system Species Region Expression system
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ALG-2/PDCD6 Fusion protein-pull down assay Human 1-66 E. coli Human Full-length HeLa lysates 19864416
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Cdc42 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ERIGC3 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSC70 Fusion protein-pull down assay Human 94-298 In vitro translation Human Full-length In vitro translation 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP40/DNAJC14 Fusion protein-pull down assay Human 94-298 In vitro translation Human Full-length In vitro translation 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4a Yeast two-hybrid Human Full-length Yeast Human 1-651 Yeast 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4b Yeast two-hybrid Human Full-length Yeast Human 79-141 Yeast 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM5 Yeast two-hybrid Human Full-length Yeast Human Not specified Yeast 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NDKA Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NovelProtein/NP9 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PEA-15 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Peroxisomal membrane protein 2 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PEX16 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Rac1 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Rac2 Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SEC31A Fusion protein-pull down assay Human 1-66 E. coli Human Full-length HeLa lysates 19864416
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Unnamed protein (BAE) Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 YIF1B Split-Ubiquitin Yeast two-hybrid Mouse Full-length Yeast Mouse Full-length Yeast 23418601
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Validation: In vivo validation Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Assay with endogenous proteins Assay with overexpressed proteins Reference
Cell or tissue Cell or tissue TRP channel construct Interactor construct
TRP channel Interactor Method Species Region Species Region
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ALG-2/PDCD6 Co-immunofluorescence staining ARPE-19 19864416
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Cdc42 Co-immunofluorescence staining RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Cdc42 Co-immunoprecipitation HeLa Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ERIGC3 Co-immunoprecipitation HeLa Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HOP/STI1 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSC70 Co-immunoprecipitation CHO Human Full-length Human Full-length 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSC70 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP40/DNAJC14 Co-immunofluorescence staining CHO Human Full-length Human Full-length 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP40/DNAJC14 Co-immunoprecipitation CHO Human Full-length Human Full-length 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP40/DNAJC14 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 HSP90 Co-immunoprecipitation CHO Human Full-length Not used 19117012
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4a Co-immunofluorescence staining ARPE-19 Human Full-length Human Full-length 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4a Co-immunoprecipitation HeLa Human Full-length Human Full-length 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4b Co-immunofluorescence staining ARPE-19 Human Full-length Human Full-length 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM4b Co-immunoprecipitation HeLa Human Full-length Human Full-length 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM5 Co-immunofluorescence staining ARPE-19 Human Full-length Human Full-length 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 LAPTM5 Co-immunoprecipitation HeLa Human Full-length Human Full-length 21224396
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NovelProtein/NP9 Co-immunofluorescence staining RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 NovelProtein/NP9 Co-immunoprecipitation HeLa Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PEA-15 Co-immunofluorescence staining RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PEX16 Split-Ubiquitin Yeast two-hybrid RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PIP5K1A Co-immunoprecipitation HeLa Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Rac1 Co-immunoprecipitation HeLa Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Rac2 Co-immunofluorescence staining RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 RhoG Co-immunofluorescence staining RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 STOML1 Co-immunofluorescence staining RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 STOML1 Co-immunoprecipitation HeLa Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 STOML1 Co-immunoprecipitation RAW264.7 macrophage Mouse Full-length Not used 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TMEM163 Co-immunoprecipitation HEK293 Mouse Full-length Mouse Full-length 25130899
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TMEM163 Co-immunoprecipitation HEK293 Human Full-length Mouse Full-length 25130899
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC1 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC1 Co-immunofluorescence staining HeLa Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC1 Co-immunofluorescence staining SK-BR-3 Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC1 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC2 Co-immunofluorescence staining HEK293T Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC2 Co-immunofluorescence staining HeLa Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC2 Co-immunofluorescence staining SK-BR-3 Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TPC2 Co-immunoprecipitation HEK293T Human Full-length Human Full-length 21540176
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Co-immunofluorescence staining HEK293 19557826
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Co-immunofluorescence staining CHO Human Full-length Human Full-length 19885840
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Co-immunoprecipitation HEK293 19557826
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Co-immunoprecipitation CHO Human Full-length Human Full-length 19885840
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Co-immunoprecipitation HEK293 Human Full-length (mutation in the pore region) Human Full-length (mutation in the pore region) 20736310
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Fluorescence resonance energy transfer HEK293 Human Full-length Human Full-length 16606612
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Co-immunofluorescence staining HEK293 19557826
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Co-immunofluorescence staining CHO Human Full-length Human Full-length 19885840
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Co-immunoprecipitation HEK293 Not specified Full-length Human Full-length 19522758
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Co-immunoprecipitation HEK293 19557826
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Co-immunoprecipitation CHO Human Full-length Human Full-length 19885840
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Co-immunoprecipitation HEK293 Human Full-length (mutation in the pore region) Human Full-length (mutation in the pore region) 20736310
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Fluorescence resonance energy transfer HEK293 Not specified Full-length Not specified Full-length 23469151
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Fluorescence resonance energy transfer HEK293 Human Full-length Mouse Full-length 16606612
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Unnamed protein (BAE) Co-immunofluorescence staining RAW264.7 macrophage Mouse Full-length Mouse Full-length 23418601
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 YIF1B Co-immunoprecipitation HeLa Mouse Full-length Mouse Full-length 23418601
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Characterization Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Binding region mapping Stoichiometry Affinity (Kd) Reference
TRP channel Interactor
TRP channel Interactor Method Species Region Species Region
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 ALG-2/PDCD6 Fusion protein-pull down assay Human 37-49 Human Not determined 19864416
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 SEC31A Fusion protein-pull down assay Human 37-49 Human Not determined 19864416
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Functional consequence Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
TRP channel Interactor Method Post-translational modification Subcellular trafficking Activity Reference
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKA In vitro PTM assay Phosphorylation (Ser-557) 17988215
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKA In vivo PTM assay Phosphorylation (Ser-559) 17988215
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 PKA Patch clamp Inhibition 17988215
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML2 Patch clamp New channel creation 19885840
TRPML1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 TRPML3 Patch clamp New channel creation 19885840
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

To prevent spam comments, we use reCAPTCHA. Please type correct words into the following box.