TRPP1 / interactors
- At a glance
- In detail
Name: Polycystin-2
(TRPP1)
Official Symbol: PKD2
provided by HGNC
Function:
Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). Functions as a calcium permeable cation channel.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
5311 |
Q13563 |
DIP-47455N |
MINT-6618167 |
111328 |
Q13563 |
504 |
hsa:5311 |
173910 |
|
|
Mouse
|
18764 |
O35245 |
202205 |
O35245 |
mmu:18764 |
|||||
|
Rat
|
498328 |
D4A5F1 |
269638 |
rno:498328 |
||||||
PPI pairs:
Biological Process:
- GO:0035904
: aorta development - GO:0001658 : branching involved in ureteric bud morphogenesis
- GO:0007050 : cell cycle arrest
- GO:0071498 : cellular response to fluid shear stress
- GO:0071464 : cellular response to hydrostatic pressure
- GO:0071470 : cellular response to osmotic stress
- GO:0034614 : cellular response to reactive oxygen species
- GO:0051298 : centrosome duplication
- GO:0042994 : cytoplasmic sequestering of transcription factor
- GO:0050982 : detection of mechanical stimulus
- GO:0003127 : detection of nodal flow
- GO:0061371 : determination of heart left/right asymmetry
- GO:0001892 : embryonic placenta development
- GO:0007507 : heart development
- GO:0007259 : JAK-STAT cascade
- GO:0001889 : liver development
- GO:0072177 : mesonephric duct development
- GO:0072218 : metanephric ascending thin limb development
- GO:0072214 : metanephric cortex development
- GO:0072219 : metanephric cortical collecting duct development
- GO:0072235 : metanephric distal tubule development
- GO:0072075 : metanephric mesenchyme development
- GO:0035502 : metanephric part of ureteric bud development
- GO:0072284 : metanephric S-shaped body morphogenesis
- GO:0072208 : metanephric smooth muscle tissue development
- GO:0008285 : negative regulation of cell proliferation
- GO:2000134 : negative regulation of G1/S transition of mitotic cell cycle
- GO:0060315 : negative regulation of ryanodine-sensitive calcium-release channel activity
- GO:0021915 : neural tube development
- GO:0060674 : placenta blood vessel development
- GO:0071158 : positive regulation of cell cycle arrest
- GO:0031659 : positive regulation of cyclin-dependent protein kinase activity involved in G1/S
- GO:0031587 : positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
- GO:0045429 : positive regulation of nitric oxide biosynthetic process
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0090279 : regulation of calcium ion import
- GO:0030814 : regulation of cAMP metabolic process
- GO:0051209 : release of sequestered calcium ion into cytosol
- GO:0061441 : renal artery morphogenesis
- GO:0061333 : renal tubule morphogenesis
- GO:0021510 : spinal cord development
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:173910
:
Polycystic kidney disease 2
(OMIM:613095 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
Screening
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
80K-H | Inference | Prediction | 19801576 | |||||
| TRPP1 |
|
ABHD12 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
ATP13A1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
BAG2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
BRI3BP | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Calnexin | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
CD2AP | Yeast two-hybrid | Mouse | 680-968 | Mouse | Embryonic | cDNA library | 10913159 | |
| TRPP1 |
|
CDKAL1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
CISD2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Cullin-1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
cullin-1 | Inference | Prediction | 17636028 | |||||
| TRPP1 |
|
DHRS7B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
DIAP1/DRF1 | Yeast two-hybrid | Human | 851-968 | Mouse | Embryonic | cDNA library | 15123714 | |
| TRPP1 |
|
EGFR | Inference | Prediction | 16135816 | |||||
| TRPP1 |
|
eIF2ơ | Inference | Prediction | 18664456 | |||||
| TRPP1 |
|
EPHA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
ERLIN2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
FAF2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Filamin-A | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
ƣ-adaptin | Inference | Prediction | 15692563 | |||||
| TRPP1 |
|
Ƣ-Trcp1 | Inference | Prediction | 17636028 | |||||
| TRPP1 |
|
Ƣ-Trcp2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Ƣ-Trcp2 | Inference | Prediction | 17636028 | |||||
| TRPP1 |
|
H2-D1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
H2-K1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
HAX-1 | Yeast two-hybrid | Human | 618-658 | Mouse | Embryonic | cDNA library | 10760273 | |
| TRPP1 |
|
HAX-1 | Yeast two-hybrid | Human | 618-658 | Human | Kidney | cDNA library | 10760273 | |
| TRPP1 |
|
HDAC6 | Inference | Prediction | 24459142 | |||||
| TRPP1 |
|
HERP | Inference | Prediction | 18178578 | |||||
| TRPP1 |
|
HSP40/DNAJA1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
ID2 | Yeast two-hybrid | Human | 679-968 | Human | Fetal kidney | cDNA library | 16311606 | |
| TRPP1 |
|
IFIT1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
IFT57 | Inference | Prediction | 15337773 | |||||
| TRPP1 |
|
IP3R1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
IP3R1 | Inference | Prediction | 16223735 | |||||
| TRPP1 |
|
IP3R3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
KIF3A | Inference | Prediction | 16950792 | |||||
| TRPP1 |
|
KIF3B | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 16950792 | |
| TRPP1 |
|
KIF3B | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 17008358 | |
| TRPP1 |
|
KIM1/TIM1 | Inference | Prediction | 18273441 | |||||
| TRPP1 |
|
KRAS | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
LAP2/TMPO | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
LETMD1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
MGST1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
NEK8 | Inference | Prediction | 18235101 | |||||
| TRPP1 |
|
Numb | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Nup155 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
ơ-actinin | Inference | Prediction | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-1 | Inference | Prediction | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-2 | Yeast two-hybrid | Human | 1-215 | Human | Heart | cDNA library | 15843396 | |
| TRPP1 |
|
p97/VCP | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
p97/VCP | Inference | Prediction | 18178578 | |||||
| TRPP1 |
|
PACS-1 | Inference | Prediction | 15692563 | |||||
| TRPP1 |
|
PACS-2 | Inference | Prediction | 15692563 | |||||
| TRPP1 |
|
Paraoxonase 3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
PDIA3/GRP58 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Pericentrin | Inference | Prediction | 15337773 | |||||
| TRPP1 |
|
PERK | Inference | Prediction | 18664456 | |||||
| TRPP1 |
|
PGAM5 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Piezo1 | Inference | Prediction | 24157948 | |||||
| TRPP1 |
|
PIGEA-14/CBY1 | Yeast two-hybrid | Human | 680-968 | Human | Kidney | cDNA library | 15194699 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Inference | Prediction | 9171830 | |||||
| TRPP1 |
|
PKD1L1/Polycystin-1L1 | Inference | Prediction | 21307093 | |||||
| TRPP1 |
|
PKHD1/FPC | Inference | Prediction | 17008358 | |||||
| TRPP1 |
|
PLCƣ2 | Inference | Prediction | 16135816 | |||||
| TRPP1 |
|
PSMD7 | Inference | Prediction | 18178578 | |||||
| TRPP1 |
|
PTP1B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RAB12 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RAB14 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RAB18 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RAB21 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RAB7 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RAD50 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RCHY1/PIRH2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Ribophorin I | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Ribophorin II | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RP2 | Inference | Prediction | 20729296 | |||||
| TRPP1 |
|
RTP4 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
RyR2 | Inference | Prediction | 17404231 | |||||
| TRPP1 |
|
SEC22B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
SEC61B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
SERCA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
SGPL1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
SKP1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
SRPRB | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
SSFA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
ST7 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
SUN3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Syntaxin5 | Yeast two-hybrid | Human | 3-213 | Mouse | Embryonic | cDNA library | 18836075 | |
| TRPP1 |
|
TAP1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TAP2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Tapasin | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TAZ/WWTR1 | Inference | Prediction | 17636028 | |||||
| TRPP1 |
|
TBL2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TFRC | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TMEM120a | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TMEM209 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TMEM48/NDC1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TMEM59 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TOR1AIP1/LAB1B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TRIM59 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Tropomyosin 1 | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 12527301 | |
| TRPP1 |
|
Troponin I 1 | Inference | Prediction | 12525172 | |||||
| TRPP1 |
|
Troponin I 2 | Inference | Prediction | 12525172 | |||||
| TRPP1 |
|
Troponin I 3 | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library | 12525172 | |
| TRPP1 |
|
TRPC1 | Inference | Prediction | 10097141 | |||||
| TRPP1 |
|
TRPC3 | Inference | Prediction | 19812035 | |||||
| TRPP1 |
|
TRPC4 | Inference | Prediction | 18256307 | |||||
| TRPP1 |
|
TRPC7 | Inference | Prediction | 19812035 | |||||
| TRPP1 |
|
TRPV4 | Inference | Prediction | 18695040 | |||||
| TRPP1 |
|
TTC35 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
TYW1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
UBC | Inference | Prediction | 18178578 | |||||
| TRPP1 |
|
UHRF1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
USE1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
VAMPA | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
VAMPB | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
VDAC3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
Viperin | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
VRK2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
| TRPP1 |
|
VTI1B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vitro validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with recombinant proteins | Reference | |||||||||
| TRP channel construct | Interactor construct | |||||||||
| TRP channel | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system | ||
| TRPP1 |
|
CD2AP | Fusion protein-pull down assay | Mouse | 747-968 | E. coli | Mouse | 331-637 | E. coli | 10913159 |
| TRPP1 |
|
HAX-1 | Yeast two-hybrid | Human | 618-658 | Yeast | Mouse | 94-280 | Yeast | 10760273 |
| TRPP1 |
|
ID2 | Yeast two-hybrid | Human | 679-968 | Yeast | Human | 1-134 | Yeast | 16311606 |
| TRPP1 |
|
KIF3A | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | In vitro translation | 16950792 |
| TRPP1 |
|
KIF3A | Yeast two-hybrid | Human | 682-968 | Yeast | Human | Full-length | Yeast | 16950792 |
| TRPP1 |
|
KIF3B | Fusion protein-pull down assay | Human | 1-215 | E. coli | Not used | Mouse inner medullary collecting duct cell lysates | 17008358 | |
| TRPP1 |
|
KIF3B | Fusion protein-pull down assay | Human | 682-968 | E. coli | Not used | Mouse inner medullary collecting duct cell lysates | 17008358 | |
| TRPP1 |
|
ơ-actinin-1 | Fusion protein-pull down assay | Human | 1-215 | E. coli | Chicken | Not specified | Not specified | 15843396 |
| TRPP1 |
|
ơ-actinin-1 | Fusion protein-pull down assay | Human | 821-968 | E. coli | Chicken | Not specified | Not specified | 15843396 |
| TRPP1 |
|
ơ-actinin-2 | Fusion protein-pull down assay | Human | 1-215 | E. coli | Chicken | Not specified | Not specified | 15843396 |
| TRPP1 |
|
ơ-actinin-2 | Fusion protein-pull down assay | Human | 821-968 | E. coli | Chicken | Not specified | Not specified | 15843396 |
| TRPP1 |
|
PACS-1 | Fusion protein-pull down assay | Human | Full-length | HEK293T lysates | Human | Full-length | Not specified | 15692563 |
| TRPP1 |
|
PACS-1 | Fusion protein-pull down assay | Not used | Mouse kidney tissue lysates | Human | Full-length | Not specified | 15692563 | |
| TRPP1 |
|
PACS-2 | Fusion protein-pull down assay | Human | Full-length | HEK293T lysates | Human | Full-length | Not specified | 15692563 |
| TRPP1 |
|
PKD1/Polycystin-1 | Yeast two-hybrid | Human | 680-968 | Yeast | Human | 1114-1339 | Yeast | 9192675 |
| TRPP1 |
|
PKD1/Polycystin-1 | Yeast two-hybrid | Human | 687-968 | Yeast | Human | 4088-4302 | Yeast | 9171830 |
| TRPP1 |
|
RyR2 | Fusion protein-pull down assay | Human | 1-703 | MDCK lysates | Not used | Mouse cardiac tissue microsome | 17404231 | |
| TRPP1 |
|
Syntaxin5 | Fusion protein-pull down assay | Human | 3-213 | E. coli | Mouse | Full-length | Not specified | 18836075 |
| TRPP1 |
|
TAZ/WWTR1 | Fusion protein-pull down assay | Mouse | 678-966 | E. coli | Mouse | 1-395 | HEK293 lysates | 17636028 |
| TRPP1 |
|
Tropomyosin 1 | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | E. coli | 12527301 |
| TRPP1 |
|
Troponin I 3 | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | E. coli | 12525172 |
| TRPP1 |
|
TRPC1 | Fusion protein-pull down assay | Human | 680-968 | In vitro translation | Human | 662-750 | E. coli | 10097141 |
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Validation: In vivo validation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference | ||||||||
| Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct | |||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPP1 |
|
80K-H | Co-immunofluorescence staining | HeLa | Human | Full-length | Not used | 19801576 | ||
| TRPP1 |
|
80K-H | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 19801576 | |
| TRPP1 |
|
CD2AP | Co-immunofluorescence staining | M-1 cell | 10913159 | |||||
| TRPP1 |
|
CD2AP | Co-immunofluorescence staining | LLC-PK1 | Human | Full-length | Mouse | Full-length | 10913159 | |
| TRPP1 |
|
CD2AP | Co-immunoprecipitation | M-1 cell | 10913159 | |||||
| TRPP1 |
|
cullin-1 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 17636028 | |||||
| TRPP1 |
|
DIAP1/DRF1 | Co-immunofluorescence staining | LLC-PK1 | 15123714 | |||||
| TRPP1 |
|
DIAP1/DRF1 | Co-immunoprecipitation | HEK293 | 15123714 | |||||
| TRPP1 |
|
EGFR | Co-immunofluorescence staining | LLC-PK1 | 16135816 | |||||
| TRPP1 |
|
EGFR | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 16135816 | |
| TRPP1 |
|
eIF2ơ | Co-immunofluorescence staining | HEK293T | Human | Full-length | Not used | 18664456 | ||
| TRPP1 |
|
eIF2ơ | Co-immunoprecipitation | Mouse Inner medullary collecting duct | 18664456 | |||||
| TRPP1 |
|
Filamin-A | Co-immunoprecipitation | COS-7 | 19879844 | |||||
| TRPP1 |
|
ƣ-adaptin | Co-immunoprecipitation | COS M6 kidney cell | 15692563 | |||||
| TRPP1 |
|
Ƣ-Trcp1 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Mouse | Full-length | 17636028 | |
| TRPP1 |
|
Ƣ-Trcp2 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Mouse | Full-length | 17636028 | |
| TRPP1 |
|
HAX-1 | Co-immunofluorescence staining | HeLa | Human | Full-length | Mouse | Full-length | 10760273 | |
| TRPP1 |
|
HAX-1 | Co-immunoprecipitation | HeLa | Human | Full-length | Mouse | Full-length | 10760273 | |
| TRPP1 |
|
HDAC6 | Co-immunoprecipitation | MDCK | 24459142 | |||||
| TRPP1 |
|
HERP | Co-immunoprecipitation | HeLa | Human | Full-length | Mouse | Full-length | 18178578 | |
| TRPP1 |
|
HERP | Co-immunoprecipitation | HEK293T | Human | Full-length | Mouse | Full-length | 19801576 | |
| TRPP1 |
|
ID2 | Co-immunofluorescence staining | HEK293T | Human | Full-length | Not used | 16311606 | ||
| TRPP1 |
|
ID2 | Co-immunoprecipitation | HEK293T | Human | Full-length | Not used | 16311606 | ||
| TRPP1 |
|
IFT57 | Co-immunoprecipitation | Tg737 Mouse 488 epithelial cell | 15337773 | |||||
| TRPP1 |
|
IP3R1 | Co-immunofluorescence staining | LLC-PK1 | Human | Full-length | Not used | 20375013 | ||
| TRPP1 |
|
IP3R1 | Co-immunoprecipitation | COS-7 | Human | Full-length | Not used | 16223735 | ||
| TRPP1 |
|
IP3R1 | Co-immunoprecipitation | Xenopus oocyte | Human | 1-741 | Not used | 16223735 | ||
| TRPP1 |
|
IP3R1 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Not used | 16223735 | ||
| TRPP1 |
|
IP3R1 | Co-immunoprecipitation | LLC-PK1 | Human | Full-length | Not used | 20375013 | ||
| TRPP1 |
|
IP3R3 | Co-immunofluorescence staining | LLC-PK1 | Human | Full-length | Not used | 20375013 | ||
| TRPP1 |
|
IP3R3 | Co-immunoprecipitation | LLC-PK1 | Human | Full-length | Not used | 20375013 | ||
| TRPP1 |
|
KIF3A | Co-immunofluorescence staining | Mouse Inner medullary collecting duct cell | 16950792 | |||||
| TRPP1 |
|
KIF3A | Co-immunofluorescence staining | MDCK | 16950792 | |||||
| TRPP1 |
|
KIF3A | Co-immunofluorescence staining | LLC-PK1 | 16950792 | |||||
| TRPP1 |
|
KIF3A | Co-immunoprecipitation | MDCK | 17283055 | |||||
| TRPP1 |
|
KIF3B | Co-immunofluorescence staining | Mouse inner medullary collecting duct cell | 17008358 | |||||
| TRPP1 |
|
KIF3B | Co-immunoprecipitation | MDCK | 17008358 | |||||
| TRPP1 |
|
KIF3B | Co-immunoprecipitation | Mouse inner medullary collecting duct cell | 17008358 | |||||
| TRPP1 |
|
KIF3B | Co-immunoprecipitation | Human kidney lysates | 17008358 | |||||
| TRPP1 |
|
KIM1/TIM1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 18273441 | |
| TRPP1 |
|
NEK8 | Co-immunofluorescence staining | Mouse kidney section | 18235101 | |||||
| TRPP1 |
|
NEK8 | Co-immunoprecipitation | Mouse kidney tissue | 18235101 | |||||
| TRPP1 |
|
NEK8 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 18235101 | |||||
| TRPP1 |
|
ơ-actinin-1 | Co-immunofluorescence staining | NIH-3T3 | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-1 | Co-immunofluorescence staining | MDCK | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-1 | Co-immunofluorescence staining | Mouse inner medullary collecting duct cell | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-1 | Co-immunoprecipitation | HEK293 | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-1 | Co-immunoprecipitation | MDCK | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-1 | Co-immunoprecipitation | Rat kidney tissue | 15843396 | |||||
| TRPP1 |
|
ơ-actinin-2 | Co-immunoprecipitation | Rat heart tissue | 15843396 | |||||
| TRPP1 |
|
p97/VCP | Co-immunofluorescence staining | MDCK | Human | Full-length | Not used | 18178578 | ||
| TRPP1 |
|
p97/VCP | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 18178578 | |||||
| TRPP1 |
|
PACS-1 | Co-immunoprecipitation | COS M6 kidney cell | 15692563 | |||||
| TRPP1 |
|
PACS-2 | Co-immunoprecipitation | COS M6 kidney cell | 15692563 | |||||
| TRPP1 |
|
Pericentrin | Co-immunofluorescence staining | RPE1 | 15337773 | |||||
| TRPP1 |
|
Pericentrin | Co-immunoprecipitation | RPE1 | 15337773 | |||||
| TRPP1 |
|
PERK | Co-immunoprecipitation | Mouse Inner medullary collecting duct | 18664456 | |||||
| TRPP1 |
|
PERK | Co-immunoprecipitation | HEK293T | Not used | Mouse | Full-length | 18664456 | ||
| TRPP1 |
|
PERK | Co-immunoprecipitation | HEK293T | Human | Full-length | Not used | 18664456 | ||
| TRPP1 |
|
Piezo1 | Co-immunoprecipitation | COS | Mouse | Full-length | Not specified | Full-length | 24157948 | |
| TRPP1 |
|
PIGEA-14/CBY1 | Co-immunofluorescence staining | HeLa | Human | Full-length | Human | Full-length | 15194699 | |
| TRPP1 |
|
PIGEA-14/CBY1 | Co-immunoprecipitation | LLC-PK1 | Human | Full-length | Human | Full-length | 15194699 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunofluorescence staining | CHO | Human | Full-length | Human | Full-length | 15060061 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunofluorescence staining | CHO | Human | Full-length | Human | Full-length | 11140688 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunofluorescence staining | PKD2-/- transgenic mouse kidney tissue | Human | Full-length | Mouse | Full-length | 12840011 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunofluorescence staining | Mouse vascular smooth muscle cell | 12937304 | |||||
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | COS-1 | 11901144 | |||||
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | Human kidney lysates | 11901144 | |||||
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | HEK293T | Human | 680-968 | Human | 1114-1339 | 9192675 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | Full-length | 23390129 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | CHO | Human | Full-length | Human | Full-length | 11140688 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | COS-7 | Human | Full-length | Mouse | 4182-4293 | 12840011 | |
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | Mouse vascular smooth muscle cell | 12937304 | |||||
| TRPP1 |
|
PKD1L1/Polycystin-1L1 | Co-immunofluorescence staining | mIMCD-3 | Mouse | Full-length | Mouse | Full-length | 21307093 | |
| TRPP1 |
|
PKD1L1/Polycystin-1L1 | Co-immunoprecipitation | HEK293T | Mouse | Full-length | Mouse | Full-length | 21307093 | |
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | Mouse kidney tissue | 18235088 | |||||
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | 3872-4074 | 18235088 | |
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | Mouse inner medulla collecting duct cell | 17008358 | |||||
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | Mouse kidney tissue | 17283055 | |||||
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | MDCK | 17283055 | |||||
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | HEK293 | Human | 1-215 | Human | 3882-4074 | 18782757 | |
| TRPP1 |
|
PLCƣ2 | Co-immunoprecipitation | HEK293T | Human | Full-length | Not specified | Full-length | 16135816 | |
| TRPP1 |
|
PSMD7 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 18178578 | |||||
| TRPP1 |
|
RP2 | Co-immunoprecipitation | Bovine retinal extract | 20729296 | |||||
| TRPP1 |
|
RP2 | Co-immunoprecipitation | MDCK | Not used | Human | Full-length | 20729296 | ||
| TRPP1 |
|
RyR2 | Co-immunoprecipitation | Mouse heart tissue | 17404231 | |||||
| TRPP1 |
|
Syntaxin5 | Co-immunofluorescence staining | LLC-PK1 | Human | Full-length | Mouse | Full-length | 18836075 | |
| TRPP1 |
|
Syntaxin5 | Co-immunoprecipitation | LLC-PK1 | Human | Full-length | Mouse | Full-length | 18836075 | |
| TRPP1 |
|
TAZ/WWTR1 | Co-immunoprecipitation | HEK293 | Mouse | Full-length | Mouse | Full-length | 17636028 | |
| TRPP1 |
|
TAZ/WWTR1 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 17636028 | |||||
| TRPP1 |
|
Tropomyosin 1 | Co-immunofluorescence staining | NIH-3T3 | Human | Full-length | Human | Full-length | 12527301 | |
| TRPP1 |
|
Tropomyosin 1 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12527301 | |
| TRPP1 |
|
Tropomyosin 1 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12527301 | |
| TRPP1 |
|
Tropomyosin 1 | Co-immunoprecipitation | HEK293 | 12527301 | |||||
| TRPP1 |
|
Tropomyosin 1 | Co-immunoprecipitation | Human kidney tissue | 12527301 | |||||
| TRPP1 |
|
Troponin I 1 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172 | |
| TRPP1 |
|
Troponin I 1 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172 | |
| TRPP1 |
|
Troponin I 2 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172 | |
| TRPP1 |
|
Troponin I 2 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172 | |
| TRPP1 |
|
Troponin I 3 | Co-immunoprecipitation | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172 | |
| TRPP1 |
|
Troponin I 3 | Co-immunoprecipitation | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172 | |
| TRPP1 |
|
Troponin I 3 | Co-immunoprecipitation | Human heart tissue | 12525172 | |||||
| TRPP1 |
|
TRPC1 | Co-immunofluorescence staining | HEK293 tsA 201 | Human | Full-length | Human | Full-length | 19850920 | |
| TRPP1 |
|
TRPC1 | Co-immunofluorescence staining | mIMCD-3 | 18323855 | |||||
| TRPP1 |
|
TRPC1 | Co-immunofluorescence staining | HEK293T | Human | Full-length | Human | Full-length | 10097141 | |
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | HEK293T | Not specified | Not specified | Human | Full-length | 14530267 | |
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | Human glomerular mesangial cell | Not used | Human | Full-length | 18256307 | ||
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Mouse | Full-length | 19812035 | |
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | HEK293 tsA 201 | Human | Full-length | Human | Full-length | 19850920 | |
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | Rat kidney tissue | 18323855 | |||||
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | HEK293 tsA 201 | Human | Full-length | Human | Full-length | 20682256 | |
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | Rat mesenteric artery endothelial cell | Human | Full-length | Human | Full-length | 25114176 | |
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | HEK293 | Human | Full-length | Human | Full-length | 25114176 | |
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | HEK293T | Human | Full-length | Human | Full-length | 10097141 | |
| TRPP1 |
|
TRPC1 | Fluorescence resonance energy transfer | HEK293 | Human | Full-length | Human | Full-length | 25114176 | |
| TRPP1 |
|
TRPC3 | Co-immunofluorescence staining | LLC-PK1 | Human | 1-697 | Not used | 19812035 | ||
| TRPP1 |
|
TRPC3 | Co-immunoprecipitation | HEK293 | Human | 1-697 | Mouse | Full-length | 19812035 | |
| TRPP1 |
|
TRPC4 | Co-immunoprecipitation | Human glomerular mesangial cell | Not used | Bovine | Full-length | 18256307 | ||
| TRPP1 |
|
TRPC7 | Co-immunoprecipitation | HEK293 | Human | 1-697 | Mouse | Full-length | 19812035 | |
| TRPP1 |
|
TRPV4 | Co-immunofluorescence staining | MDCK | 18695040 | |||||
| TRPP1 |
|
TRPV4 | Co-immunofluorescence staining | Mouse orpk collecting duct cell line | 23977387 | |||||
| TRPP1 |
|
TRPV4 | Co-immunoprecipitation | HEK293 tsA 201 | Human | Full-length | Mouse | Full-length | 20682256 | |
| TRPP1 |
|
TRPV4 | Co-immunoprecipitation | Rat mesenteric artery endothelial cell | Human | Full-length | Mouse | Full-length | 25114176 | |
| TRPP1 |
|
TRPV4 | Co-immunoprecipitation | HEK293 | Human | Full-length | Mouse | Full-length | 25114176 | |
| TRPP1 |
|
TRPV4 | Co-immunoprecipitation | HEK293 | Human | C-terminus | Mouse | C-terminus | 18695040 | |
| TRPP1 |
|
TRPV4 | Co-immunoprecipitation | Mouse inner medullary collecting duct cell | 23977387 | |||||
| TRPP1 |
|
TRPV4 | Co-immunoprecipitation | Mouse orpk collecting duct cell line | 23977387 | |||||
| TRPP1 |
|
TRPV4 | Fluorescence resonance energy transfer | HEK293 | Human | Full-length | Mouse | Full-length | 25114176 | |
| TRPP1 |
|
TRPV4 | Fluorescence resonance energy transfer | HEK293 | Human | Full-length | Mouse | Full-length | 18695040 | |
| TRPP1 |
|
UBC | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell | 18178578 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Characterization
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference | |||||||
| TRP channel | Interactor | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Region | ||||
| TRPP1 |
|
CD2AP | Fusion protein-pull down assay | Mouse | 747-968 | Mouse | 331-637 | 10913159 | ||
| TRPP1 |
|
DIAP1/DRF1 | Co-immunoprecipitation | Human | 679-968 | Mouse | 543-1203 | 15123714 | ||
| TRPP1 |
|
EGFR | Co-immunoprecipitation | Human | 1-871 | Human | Not determined | 16135816 | ||
| TRPP1 |
|
HAX-1 | Yeast two-hybrid | Human | 618-658 | Mouse | 179-280 | 10760273 | ||
| TRPP1 |
|
HERP | Co-immunoprecipitation | Human | 689-968 | Mouse | Not determined | 18178578 | ||
| TRPP1 |
|
HERP | Co-immunoprecipitation | Human | 1-208 | Mouse | Not determined | 18178578 | ||
| TRPP1 |
|
ID2 | Yeast two-hybrid | Human | 679-968 | Human | 30-84 | 16311606 | ||
| TRPP1 |
|
IP3R1 | Fusion protein-pull down assay | Human | Not determined | Human | 1-345 | 20375013 | ||
| TRPP1 |
|
KIF3A | Fusion protein-pull down assay | Human | 682-968 | Human | 403-702 | 17008358 | ||
| TRPP1 |
|
KIF3A | Yeast two-hybrid | Human | 872-927 | Human | 403-702 | 16950792 | ||
| TRPP1 |
|
KIF3B | Fusion protein-pull down assay | Human | 682-968 | Human | 407-747 | 17008358 | ||
| TRPP1 |
|
KIF3B | Yeast two-hybrid | Human | 1-215 | Human | 407-747 | 17008358 | ||
| TRPP1 |
|
KIM1/TIM1 | Co-immunoprecipitation | Human | 1-30 | Human | Not determined | 18273441 | ||
| TRPP1 |
|
ơ-actinin-1 | Fusion protein-pull down assay | Human | 821-878 | Chicken | Not determined | 15843396 | ||
| TRPP1 |
|
ơ-actinin-1 | Yeast two-hybrid | Human | 821-878 | Human | 334-892 | 15843396 | ||
| TRPP1 |
|
ơ-actinin-2 | Fusion protein-pull down assay | Human | 821-878 | Chicken | Not determined | 15843396 | ||
| TRPP1 |
|
ơ-actinin-2 | Yeast two-hybrid | Human | 1-215 | Human | 341-894 | 15843396 | ||
| TRPP1 |
|
ơ-actinin-2 | Yeast two-hybrid | Human | 1-215 | Human | 596-728 | 15843396 | ||
| TRPP1 |
|
ơ-actinin-2 | Yeast two-hybrid | Human | 821-878 | Human | 341-894 | 15843396 | ||
| TRPP1 |
|
PACS-1 | Fluorescence probe labeling | 14.8 ƬM | 15692563 | |||||
| TRPP1 |
|
PACS-1 | Fusion protein-pull down assay | Human | 741-871 | Human | 115-255 | 15692563 | ||
| TRPP1 |
|
PACS-2 | Fluorescence probe labeling | 15.4 ƬM | 15692563 | |||||
| TRPP1 |
|
PACS-2 | Fusion protein-pull down assay | Human | Not determined | Human | 117-266 | 15692563 | ||
| TRPP1 |
|
Piezo1 | Co-immunoprecipitation | Mouse | N-terminus | Not specified | Not determined | 24157948 | ||
| TRPP1 |
|
PIGEA-14/CBY1 | Yeast two-hybrid | Human | 680-968 | Human | 60-112 | 15194699 | ||
| TRPP1 |
|
PIGEA-14/CBY1 | Yeast two-hybrid | Human | 833-923 | Human | Not determined | 15194699 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | Human | 742-968 | Human | 4227-4303 | 11140688 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunoprecipitation | Human | 680-968 | Human | 1227-1339 | 9192675 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 681-968 | Not specified | 4077-4302 | 15692563 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 742-872 | Human | 4214-4248 | 9171830 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 833-895 | Human | 4213-4248 | 19556541 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 821-927 | Mouse | 4183-4270 | 19726544 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Yeast two-hybrid | Human | 742-872 | Human | 4214-4248 | 9171830 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Yeast two-hybrid | Human | 742-968 | Human | 1227-1339 | 9192675 | ||
| TRPP1 |
|
PKD1/Polycystin-1 | Yeast two-hybrid | Human | 822-895 | Human | 4124-4303 | 10097141 | ||
| TRPP1 |
|
PKD1L1/Polycystin-1L1 | Co-immunoprecipitation | Mouse | Full-length | Mouse | 2440-2607 | 21307093 | ||
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | Human | 1-221 | Human | 3872-4074 | 18235088 | ||
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | Human | Not determined | Human | 3850-4074 | 17008358 | ||
| TRPP1 |
|
PKHD1/FPC | Co-immunoprecipitation | Human | 90-139 | Human | 3903-3964 | 18782757 | ||
| TRPP1 |
|
PLCƣ2 | Co-immunoprecipitation | Human | 1-379 | Not specified | Not determined | 16135816 | ||
| TRPP1 |
|
RyR2 | Fusion protein-pull down assay | Human | 703-968 | Mouse | Not determined | 17404231 | ||
| TRPP1 |
|
RyR2 | Fusion protein-pull down assay | Human | 130-220 | Mouse | Not determined | 17404231 | ||
| TRPP1 |
|
Syntaxin5 | Co-immunoprecipitation | Human | 5-72 | Mouse | Not determined | 18836075 | ||
| TRPP1 |
|
Syntaxin5 | Fusion protein-pull down assay | Human | Not determined | Mouse | 256-333 | 18836075 | ||
| TRPP1 |
|
TAZ/WWTR1 | Fusion protein-pull down assay | Mouse | 678-966 | Mouse | 220-272 | 17636028 | ||
| TRPP1 |
|
Tropomyosin 1 | Yeast two-hybrid | Human | 821-878 | Human | 152-196 | 12527301 | ||
| TRPP1 |
|
Troponin I 3 | Yeast two-hybrid | Human | 872-927 | Human | 1-107 | 12525172 | ||
| TRPP1 |
|
Troponin I 3 | Yeast two-hybrid | Human | 872-927 | Human | 106-158 | 12525172 | ||
| TRPP1 |
|
TRPC1 | Atomic force microscopy(AFM) analysis | 2:2 | 19850920 | |||||
| TRPP1 |
|
TRPC1 | Atomic force microscopy(AFM) analysis | 2:2 | 19193631 | |||||
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | Human | 1-643 | Human | Not determined | 10097141 | ||
| TRPP1 |
|
TRPC1 | Co-immunoprecipitation | Human | 679-968 | Human | Not determined | 10097141 | ||
| TRPP1 |
|
TRPC1 | Yeast two-hybrid | Human | 822-895 | Human | 639-750 | 10097141 | ||
| TRPP1 |
|
TRPC3 | Fusion protein-pull down assay | Human | 1-697 | Mouse | 659-753 | 19812035 | ||
| TRPP1 |
|
TRPV4 | Atomic force microscopy(AFM) analysis | 2:2 | 20682256 | |||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
|
Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
|
top
|
| Functional consequence
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TRP channel | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference | ||||||
| TRPP1 |
|
80K-H | Co-immunofluorescence staining | Retain in the endoplasmic reticulum | 19801576 | |||||||
| TRPP1 |
|
KIF3A | Patch clamp | Activation | 16950792 | |||||||
| TRPP1 |
|
ơ-actinin | Patch clamp | Activation | 15843396 | |||||||
| TRPP1 |
|
PKA | In vitro PTM assay | Phosphorylation (Ser-829) | 23390129 | |||||||
| TRPP1 |
|
PKD1/Polycystin-1 | Co-immunofluorescence staining | Increase in plasma membrane level | 11140688 | |||||||
| TRPP1 |
|
PKD1/Polycystin-1 | Patch clamp | New channel creation | 11140688 | |||||||
| TRPP1 |
|
Syntaxin5 | Patch clamp | Inhibition | 18836075 | |||||||
| TRPP1 |
|
TRPC1 | Patch clamp | New channel creation | 18323855 | |||||||
| TRPP1 |
|
TRPC1 | Patch clamp | New channel creation | 25114176 | |||||||
| TRPP1 |
|
TRPV4 | Patch clamp | New channel creation | 25114176 | |||||||
| TRPP1 |
|
TRPV4 | Patch clamp | New channel creation | 18695040 | |||||||
(:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)