Tapasin / TRP channels

Name: Tapasin (Tapasin)
Official Symbol: TAPBP provided by HGNC
Function:
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).
Species External DB Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984
Entrez Gene UniprotKB DIP IntAct MINT BioGRID STRING IUPHAR-DB KEGG OMIM
Human
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		6892External O15533External DIP-36063NExternal O15533External MINT-4053688External 112755External O15533External   hsa:6892External 601962External
Mouse
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		21356External Q9R233External     MINT-4138357External 203968External Q9R233External   mmu:21356External  
Rat
Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f 		25217External Q99JC6External       247259External Q99JC6External   rno:25217External  
PPI pairs:
Biological Process:
  • GO:0019885 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of endogenous peptide antigen via MHC class I
  • GO:0002479 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • GO:0006952 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : defense response
  • GO:0006955 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : immune response
  • GO:0050823 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : peptide antigen stabilization
  • GO:0006461 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : protein complex assembly
  • GO:0006890 External 2231691f894ba696de1310221b0a0dbbb31a7251e75115c265587c3d9d5f507c : retrograde vesicle-mediated transport, Golgi to ER
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Screening Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b Functional consequence Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b top
Screening Toggle 893349bafcc528f8346c51dc3420151d67b0126b2c122dd1017121c03fa0f69b
  Experimental screening Non-experimental screening Reference
TRP channel construct Interactor source
TRP channel Interactor Method Species Region Species Organ/tissue Sample type
TRPP1 Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4 Tapasin Affinity purification-mass spectrometry Mouse Not specified Mouse Vascular smooth muscle MOVAS lysates 19879844
(Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
TRP / Interactor

To prevent spam comments, we use reCAPTCHA. Please type correct words into the following box.