Tenascin-R / TRP channels
Name: Tenascin-R
(Tenascin-R)
Official Symbol: TNR
provided by HGNC
Function:
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
7143 |
Q92752 |
Q92752 |
112997 |
Q92752 |
hsa:7143 |
601995 |
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|
Mouse
|
21960 |
Q8BYI9 |
Q8BYI9 |
204272 |
Q8BYI9 |
mmu:21960 |
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|
Rat
|
25567 |
Q05546 |
Q05546 |
247598 |
Q05546 |
rno:25567 |
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PPI pairs:
Biological Process:
- GO:0008306
: associative learning - GO:0007411 : axon guidance
- GO:0007155 : cell adhesion
- GO:0030198 : extracellular matrix organization
- GO:0035641 : locomotory exploration behavior
- GO:0060291 : long-term synaptic potentiation
- GO:0048692 : negative regulation of axon extension involved in regeneration
- GO:0022408 : negative regulation of cell-cell adhesion
- GO:0050805 : negative regulation of synaptic transmission
- GO:0050885 : neuromuscular process controlling balance
- GO:0007158 : neuron cell-cell adhesion
- GO:0051968 : positive regulation of synaptic transmission, glutamatergic
- GO:0007165 : signal transduction
- GO:0050808 : synapse organization
- GO:0022029 : telencephalon cell migration
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPC3 |
|
Tenascin-R | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 | ||
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)