VAMPB / TRP channels
Name: Vesicle-associated membrane protein-associated protein B/C
(VAMPB)
Official Symbol: VAPB
provided by HGNC
Function:
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
| Species |
External DB
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
|
9217 |
O95292 |
DIP-39816N |
O95292 |
MINT-3002838 |
114650 |
O95292 |
hsa:9217 |
605704 |
|
|
Mouse
|
56491 |
Q9QY76 |
DIP-32207N |
Q9QY76 |
208016 |
Q9QY76 |
mmu:56491 |
|||
|
Rat
|
60431 |
Q9Z269 |
DIP-57372N |
MINT-4566897 |
248831 |
Q9Z269 |
rno:60431 |
|||
PPI pairs:
Biological Process:
- GO:0006987
: activation of signaling protein activity involved in unfolded protein response - GO:0008219 : cell death
- GO:0006874 : cellular calcium ion homeostasis
- GO:0006644 : phospholipid metabolic process
- GO:0045070 : positive regulation of viral genome replication
- GO:0044281 : small molecule metabolic process
- GO:0030148 : sphingolipid biosynthetic process
- GO:0019048 : virus-host interaction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
- OMIM:605704
:
Amyotrophic lateral sclerosis 8
(OMIM:608627 )
- OMIM:605704
:
Spinal muscular atrophy, late-onset, Finkel type
(OMIM:182980 )
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
 Screening
Validation: In vitro validation
Validation: In vivo validation
Characterization
Functional consequence
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top
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Screening
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|---|---|---|---|---|---|---|---|---|---|---|
| Experimental screening | Non-experimental screening | Reference | ||||||||
| TRP channel construct | Interactor source | |||||||||
| TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
| TRPP1 |
|
VAMPB | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates | 19879844 | |
(:
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:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)