VDAC1 / TRP channels
Name: Voltage-dependent anion-selective channel protein 1
(VDAC1)
Official Symbol: VDAC1
provided by HGNC
Function:
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt)
Nucleic Acids Res. 40: D71-D75 (2012).
Species |
External DB
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Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM | |
Human
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7416![]() |
P21796![]() |
DIP-32862N![]() |
P21796![]() |
MINT-5002499![]() |
113259![]() |
P21796![]() |
hsa:7416![]() |
604492![]() |
|
Mouse
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22333![]() |
Q60932![]() |
Q60932![]() |
204507![]() |
Q60932![]() |
mmu:22333![]() |
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Rat
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83529![]() |
Q9Z2L0![]() |
Q9Z2L0![]() |
MINT-1541752![]() |
249746![]() |
Q9Z2L0![]() |
rno:83529![]() |
PPI pairs:
Biological Process:
- GO:0006915
: apoptotic process
- GO:0001662
: behavioral fear response
- GO:0007612
: learning
- GO:0007270
: neuron-neuron synaptic transmission
- GO:0019048
: virus-host interaction
Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
World Wide Web URL: http://www.geneontology.org/
Disease:
No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/
World Wide Web URL: http://omim.org/
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Screening
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Experimental screening | Non-experimental screening | Reference | ||||||||
TRP channel construct | Interactor source | |||||||||
TRP channel | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type | |||
TRPC3 |
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VDAC1 | Affinity purification-mass spectrometry | Not used as a bait | Rat | Brain | Crude membranes | 18205297 |
(
:
click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
