TRP channels

TRPC
- TRPC1
- TRPC2
- TRPC3
- TRPC4
- TRPC5
- TRPC6
- TRPC7
TRPV
- TRPV1
- TRPV2
- TRPV3
- TRPV4
- TRPV5
- TRPV6
TRPM
- TRPM1
- TRPM2
- TRPM3
- TRPM4
- TRPM5
- TRPM6
- TRPM7
- TRPM8
TRPML
- TRPML1
- TRPML2
- TRPML3
TRPP
- TRPP1
- TRPP2
- TRPP3
TRPA
- TRPA1

» Citation

Nar2011 9c5ccb7544ea9ea0a4b3599ccec8bea610f3995142d5da2da0189fad9f699236

Plos2012 71954aaff6a4569630a779eb6502d687ff86630adfca3a1cc207b9836b808980

Pf2013 33c9f49bb4f61555bed5365c90448ebe56e96eb338f5692f7ef4b8a5db693247

eNOS / TRP channels

Basic Information
External Database
PPI pairs (1)
Biological Process (47)
Disease (6)

Name: Nitric oxide synthase, endothelial (eNOS)

Official Symbol: NOS3 provided by HGNC

Function:

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.

Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species

External DB

Questionmark c7dcdfe7852228a510704064c33a0706d8c0e915bceea718517e77f7950c2984

Entrez Gene

UniprotKB

DIP

IntAct

MINT

BioGRID

STRING

IUPHAR-DB

KEGG

OMIM

Human

Seq 055e86e69a1b9fa3c345494da0168454ea5fcb72eb0f6a154a55bbbbbcb46d2f

Mouse

Rat

PPI pairs:

Biological Process:

GO:0007568 : aging
GO:0001525 : angiogenesis
GO:0006527 : arginine catabolic process
GO:0007596 : blood coagulation
GO:0001974 : blood vessel remodeling
GO:0071560 : cellular response to transforming growth factor beta stimulus
GO:0043542 : endothelial cell migration
GO:0001701 : in utero embryonic development
GO:0051701 : interaction with host
GO:0031663 : lipopolysaccharide-mediated signaling pathway
GO:0030324 : lung development
GO:0007005 : mitochondrion organization
GO:0043066 : negative regulation of apoptotic process
GO:0045776 : negative regulation of blood pressure
GO:0051926 : negative regulation of calcium ion transport
GO:0008285 : negative regulation of cell proliferation
GO:0051346 : negative regulation of hydrolase activity
GO:0014740 : negative regulation of muscle hyperplasia
GO:0010544 : negative regulation of platelet activation
GO:0043267 : negative regulation of potassium ion transport
GO:0048662 : negative regulation of smooth muscle cell proliferation
GO:0006809 : nitric oxide biosynthetic process
GO:0007263 : nitric oxide mediated signal transduction
GO:0001542 : ovulation from ovarian follicle
GO:0090382 : phagosome maturation
GO:0045766 : positive regulation of angiogenesis
GO:0043065 : positive regulation of apoptotic process
GO:0031284 : positive regulation of guanylate cyclase activity
GO:0045909 : positive regulation of vasodilation
GO:0050880 : regulation of blood vessel size
GO:0050999 : regulation of nitric-oxide synthase activity
GO:0002028 : regulation of sodium ion transport
GO:0003100 : regulation of systemic arterial blood pressure by endothelin
GO:0043200 : response to amino acid stimulus
GO:0034097 : response to cytokine stimulus
GO:0042493 : response to drug
GO:0032355 : response to estradiol stimulus
GO:0045471 : response to ethanol
GO:0034405 : response to fluid shear stress
GO:0009408 : response to heat
GO:0055093 : response to hyperoxia
GO:0001666 : response to hypoxia
GO:0010288 : response to lead ion
GO:0055094 : response to lipoprotein particle stimulus
GO:0009612 : response to mechanical stimulus
GO:0043434 : response to peptide hormone stimulus
GO:0014806 : smooth muscle hyperplasia

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/

Disease:

OMIM:163729 : Coronary artery spasm 1, susceptibility to (OMIM: )
OMIM:163729 : Alzheimer disease, late-onset, susceptibility to (OMIM:104300 )
OMIM:163729 : Hypertension, susceptibility to (OMIM:145500 )
OMIM:163729 : Hypertension, pregnancy-induced (OMIM:189800 )
OMIM:163729 : Placental abruption (OMIM: )
OMIM:163729 : Ischemic stroke, susceptibility to (OMIM:601367 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

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Screening
			Experimental screening					Non-experimental screening	Reference
			TRP channel construct		Interactor source
TRP channel	Interactor	Method	Species	Region	Species	Organ/tissue	Sample type
TRPV1	eNOS	Inference						Prediction	21493704

(

Link 2bd4d11adb659cddf58197a94e201f0a44c55d8d7cb427c624971b42e122c0a4

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening

Validation: In vitro validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Validation: In vivo validation Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Characterization Arrow2 1fb2b8a5ad55723bad55961567d092af30310a7cf44ded6f695fc2aa4753ec2b

Functional consequence

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Validation: In vivo validation
			Assay with endogenous proteins	Assay with overexpressed proteins					Reference
			Cell or tissue	Cell or tissue	TRP channel construct		Interactor construct
TRP channel	Interactor	Method	Cell or tissue	Cell or tissue	Species	Region	Species	Region
TRPV1	eNOS	Co-immunoprecipitation	Bovine aortic endothelial cells						21493704
TRPV1	eNOS	Co-immunoprecipitation	Bovine aortic endothelial cells						22451268
TRPV1	eNOS	Mammalian two-hybrid		Bovine aortic endothelial cells	Rat	Full-length	Human	Full-length	22451268

(

: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

TRIP Database

eNOS / TRP channels